TY - JOUR
T1 - Passive immunization of mice against D factor blocks lethality and cytokine release during endotoxemia
AU - Block, Mark I.
AU - Berg, Maria
AU - McNamara, Michael J.
AU - Norton, Jeffrey A.
AU - Fraker, Douglas L.
AU - Alexander, H. Richard
PY - 1993/9/1
Y1 - 1993/9/1
N2 - D factor, also known as leukemia inhibitory factor, is a pleiotropic cytokine whose role during acute injury and inflammation is not known. Intraperitoneal administration of Escherichia coli endotoxin induced D factor gene expression in mice, and passive immunization against D factor protected them from the lethal effects of endotoxin and blocked endotoxin-induced increases in serum levels of interleukin 1 and 6. Peak levels of tumor necrosis factor and interferon 7 were not affected. These results indicate that D factor is an essential early mediator of the inflammatory cytokine response and therefore may be important in the pathogenesis of the many inflammatory conditions, such as sepsis, arthritis, allograft rejection, and cancer immunotherapy.
AB - D factor, also known as leukemia inhibitory factor, is a pleiotropic cytokine whose role during acute injury and inflammation is not known. Intraperitoneal administration of Escherichia coli endotoxin induced D factor gene expression in mice, and passive immunization against D factor protected them from the lethal effects of endotoxin and blocked endotoxin-induced increases in serum levels of interleukin 1 and 6. Peak levels of tumor necrosis factor and interferon 7 were not affected. These results indicate that D factor is an essential early mediator of the inflammatory cytokine response and therefore may be important in the pathogenesis of the many inflammatory conditions, such as sepsis, arthritis, allograft rejection, and cancer immunotherapy.
UR - https://www.scopus.com/pages/publications/0027304410
UR - https://www.scopus.com/pages/publications/0027304410#tab=citedBy
M3 - Article
C2 - 8350047
SN - 0022-1007
VL - 178
SP - 1085
EP - 1090
JO - Journal of Experimental Medicine
JF - Journal of Experimental Medicine
IS - 3
ER -