Path Analysis Reveals the Direct Effect of PCB28 Exposure on Cognitive Dysfunction in Older Chinese Females

Chenwei Pan; Huijuan Zhao; Qiaoling Du; Yong Xu; Dajun Tian; Shuo Xiao; Haiyin Wang; Xiao Wei; Chunfeng Wu; Yuanyuan Ruan; Chunhua Zhao; Gonghua Tao; Weiwei Zheng

doi:https://doi.org/10.3390/ijerph19126958

Path Analysis Reveals the Direct Effect of PCB28 Exposure on Cognitive Dysfunction in Older Chinese Females

Chenwei Pan, Huijuan Zhao, Qiaoling Du, Yong Xu, Dajun Tian, Shuo Xiao, Haiyin Wang, Xiao Wei, Chunfeng Wu, Yuanyuan Ruan, Chunhua Zhao, Gonghua Tao, Weiwei Zheng

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Research indicates that exposure to polychlorinated biphenyls (PCBs) can cause neurobehavioral impairments in neonates and adults, but the way specific PCBs’ congeners impact cognition functions at a low exposure level in a real-life co-exposure system remains poorly understood. This study aimed to investigate the association of PCBs burden with cognition function among elderly adults. Methods: Based on the Weitang Geriatric Diseases study (2014–2015), the current study measured the plasma concentrations of six indicator-PCBs by GC-MS/MS and assessed the cognitive dysfunction (CoD) via an Abbreviated Mental Test in 266 participants (ages 61–90). Sequential logistic regression was used to analyze the effects of PCBs on cognition functions. Female participants aged less than or equal to 80 years were selected, and path analysis was used to determine the direct or indirect impacts of co-exposure PCBs on CoD by structural equation modeling. Results: After sequential adjustments to potential confounding factors and correction by the Bonferroni, no statistically significant correlation between PCBs exposure and CoD was found in participants (p > 0.05). However, in the co-exposure system, after controlling for co-exposures and confounders, exposure to PCB28 had a direct effect on CoD in females aged between 61 and 80, with a factor load of 0.670. Conclusions: After adjusting for the co-exposures and confounders, exposure to PCB28 can directly increase the risk of cognitive impairment in older Chinese females.

Original language	American English
Article number	6958
Journal	International journal of environmental research and public health
Volume	19
Issue number	12
DOIs	https://doi.org/10.3390/ijerph19126958
State	Published - Jun 1 2022
Externally published	Yes

ASJC Scopus subject areas

Pollution
Public Health, Environmental and Occupational Health
Health, Toxicology and Mutagenesis

Keywords

Abbreviated Mental Test
cognitive dysfunction
older females
path analysis
polychlorinated biphenyls

Access to Document

https://doi.org/10.3390/ijerph19126958

Cite this

@article{0701de00e5244946996f5b34faa82ba2,

title = "Path Analysis Reveals the Direct Effect of PCB28 Exposure on Cognitive Dysfunction in Older Chinese Females",

abstract = "Background: Research indicates that exposure to polychlorinated biphenyls (PCBs) can cause neurobehavioral impairments in neonates and adults, but the way specific PCBs{\textquoteright} congeners impact cognition functions at a low exposure level in a real-life co-exposure system remains poorly understood. This study aimed to investigate the association of PCBs burden with cognition function among elderly adults. Methods: Based on the Weitang Geriatric Diseases study (2014–2015), the current study measured the plasma concentrations of six indicator-PCBs by GC-MS/MS and assessed the cognitive dysfunction (CoD) via an Abbreviated Mental Test in 266 participants (ages 61–90). Sequential logistic regression was used to analyze the effects of PCBs on cognition functions. Female participants aged less than or equal to 80 years were selected, and path analysis was used to determine the direct or indirect impacts of co-exposure PCBs on CoD by structural equation modeling. Results: After sequential adjustments to potential confounding factors and correction by the Bonferroni, no statistically significant correlation between PCBs exposure and CoD was found in participants (p > 0.05). However, in the co-exposure system, after controlling for co-exposures and confounders, exposure to PCB28 had a direct effect on CoD in females aged between 61 and 80, with a factor load of 0.670. Conclusions: After adjusting for the co-exposures and confounders, exposure to PCB28 can directly increase the risk of cognitive impairment in older Chinese females.",

keywords = "Abbreviated Mental Test, cognitive dysfunction, older females, path analysis, polychlorinated biphenyls",

author = "Chenwei Pan and Huijuan Zhao and Qiaoling Du and Yong Xu and Dajun Tian and Shuo Xiao and Haiyin Wang and Xiao Wei and Chunfeng Wu and Yuanyuan Ruan and Chunhua Zhao and Gonghua Tao and Weiwei Zheng",

note = "Funding Information: This work was supported by the National Natural Science Foundation of China (No. 82122058 & 81773379 & 81202165), Key Young Talents Training Program for Shanghai Disease Control and Prevention (21QNGG10), the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD), the Shanghai Municipal Commission of Health and the Family Foundation for the Fifth Round of the Three-Year Public Health Action Plan of Shanghai (GWV-1.1 & GWV-10.1-XK08), for General Program (202040186) and for Young Talents (2017YQ023), the Natural Science Foundation of Shanghai (21 ZR1438400). Publisher Copyright: {\textcopyright} 2022 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2022",

month = jun,

day = "1",

doi = "https://doi.org/10.3390/ijerph19126958",

language = "American English",

volume = "19",

journal = "International journal of environmental research and public health",

issn = "1661-7827",

publisher = "Multidisciplinary Digital Publishing Institute",

number = "12",

}

TY - JOUR

T1 - Path Analysis Reveals the Direct Effect of PCB28 Exposure on Cognitive Dysfunction in Older Chinese Females

AU - Pan, Chenwei

AU - Zhao, Huijuan

AU - Du, Qiaoling

AU - Xu, Yong

AU - Tian, Dajun

AU - Xiao, Shuo

AU - Wang, Haiyin

AU - Wei, Xiao

AU - Wu, Chunfeng

AU - Ruan, Yuanyuan

AU - Zhao, Chunhua

AU - Tao, Gonghua

AU - Zheng, Weiwei

N1 - Funding Information: This work was supported by the National Natural Science Foundation of China (No. 82122058 & 81773379 & 81202165), Key Young Talents Training Program for Shanghai Disease Control and Prevention (21QNGG10), the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD), the Shanghai Municipal Commission of Health and the Family Foundation for the Fifth Round of the Three-Year Public Health Action Plan of Shanghai (GWV-1.1 & GWV-10.1-XK08), for General Program (202040186) and for Young Talents (2017YQ023), the Natural Science Foundation of Shanghai (21 ZR1438400). Publisher Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland.

PY - 2022/6/1

Y1 - 2022/6/1

N2 - Background: Research indicates that exposure to polychlorinated biphenyls (PCBs) can cause neurobehavioral impairments in neonates and adults, but the way specific PCBs’ congeners impact cognition functions at a low exposure level in a real-life co-exposure system remains poorly understood. This study aimed to investigate the association of PCBs burden with cognition function among elderly adults. Methods: Based on the Weitang Geriatric Diseases study (2014–2015), the current study measured the plasma concentrations of six indicator-PCBs by GC-MS/MS and assessed the cognitive dysfunction (CoD) via an Abbreviated Mental Test in 266 participants (ages 61–90). Sequential logistic regression was used to analyze the effects of PCBs on cognition functions. Female participants aged less than or equal to 80 years were selected, and path analysis was used to determine the direct or indirect impacts of co-exposure PCBs on CoD by structural equation modeling. Results: After sequential adjustments to potential confounding factors and correction by the Bonferroni, no statistically significant correlation between PCBs exposure and CoD was found in participants (p > 0.05). However, in the co-exposure system, after controlling for co-exposures and confounders, exposure to PCB28 had a direct effect on CoD in females aged between 61 and 80, with a factor load of 0.670. Conclusions: After adjusting for the co-exposures and confounders, exposure to PCB28 can directly increase the risk of cognitive impairment in older Chinese females.

AB - Background: Research indicates that exposure to polychlorinated biphenyls (PCBs) can cause neurobehavioral impairments in neonates and adults, but the way specific PCBs’ congeners impact cognition functions at a low exposure level in a real-life co-exposure system remains poorly understood. This study aimed to investigate the association of PCBs burden with cognition function among elderly adults. Methods: Based on the Weitang Geriatric Diseases study (2014–2015), the current study measured the plasma concentrations of six indicator-PCBs by GC-MS/MS and assessed the cognitive dysfunction (CoD) via an Abbreviated Mental Test in 266 participants (ages 61–90). Sequential logistic regression was used to analyze the effects of PCBs on cognition functions. Female participants aged less than or equal to 80 years were selected, and path analysis was used to determine the direct or indirect impacts of co-exposure PCBs on CoD by structural equation modeling. Results: After sequential adjustments to potential confounding factors and correction by the Bonferroni, no statistically significant correlation between PCBs exposure and CoD was found in participants (p > 0.05). However, in the co-exposure system, after controlling for co-exposures and confounders, exposure to PCB28 had a direct effect on CoD in females aged between 61 and 80, with a factor load of 0.670. Conclusions: After adjusting for the co-exposures and confounders, exposure to PCB28 can directly increase the risk of cognitive impairment in older Chinese females.

KW - Abbreviated Mental Test

KW - cognitive dysfunction

KW - older females

KW - path analysis

KW - polychlorinated biphenyls

UR - http://www.scopus.com/inward/record.url?scp=85131377324&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85131377324&partnerID=8YFLogxK

U2 - https://doi.org/10.3390/ijerph19126958

DO - https://doi.org/10.3390/ijerph19126958

M3 - Article

C2 - 35742207

SN - 1661-7827

VL - 19

JO - International journal of environmental research and public health

JF - International journal of environmental research and public health

IS - 12

M1 - 6958

ER -

Path Analysis Reveals the Direct Effect of PCB28 Exposure on Cognitive Dysfunction in Older Chinese Females

Abstract

ASJC Scopus subject areas

Keywords

Access to Document

Other files and links

Fingerprint

Cite this