Patterns of genetic variation in mendelian and complex traits

Michael E. Zwick; David J. Cutler; Aravinda Chakravarti

doi:https://doi.org/10.1146/annurev.genom.1.1.387

Patterns of genetic variation in mendelian and complex traits

Michael E. Zwick, David J. Cutler, Aravinda Chakravarti

Research output: Contribution to journal › Review article › peer-review

Abstract

This review discusses the prospects for understanding the genetic basis of complex traits in humans. We take the view that work done on Drosophila melanogaster can serve as a model for understanding complex traits in humans, and the literature on this model system, as well as on humans, is reviewed. The prospects for success in understanding the genetic basis of complex traits depend, in part, on the nature of the forces acting on genetic variation. We suggest that different experimental approaches should be undertaken for traits caused by common genetic variants versus those arising from rare genetic variants.

Original language	American English
Pages (from-to)	387-407
Number of pages	21
Journal	Annual Review of Genomics and Human Genetics
Volume	1
Issue number	2000
DOIs	https://doi.org/10.1146/annurev.genom.1.1.387
State	Published - 2000
Externally published	Yes

ASJC Scopus subject areas

Molecular Biology
Genetics
Genetics(clinical)

Keywords

Drosophila sensory bristles
Human complex traits
Single nucleotide polymorphisms (SNPs)

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https://doi.org/10.1146/annurev.genom.1.1.387

Cite this

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abstract = "This review discusses the prospects for understanding the genetic basis of complex traits in humans. We take the view that work done on Drosophila melanogaster can serve as a model for understanding complex traits in humans, and the literature on this model system, as well as on humans, is reviewed. The prospects for success in understanding the genetic basis of complex traits depend, in part, on the nature of the forces acting on genetic variation. We suggest that different experimental approaches should be undertaken for traits caused by common genetic variants versus those arising from rare genetic variants.",

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AB - This review discusses the prospects for understanding the genetic basis of complex traits in humans. We take the view that work done on Drosophila melanogaster can serve as a model for understanding complex traits in humans, and the literature on this model system, as well as on humans, is reviewed. The prospects for success in understanding the genetic basis of complex traits depend, in part, on the nature of the forces acting on genetic variation. We suggest that different experimental approaches should be undertaken for traits caused by common genetic variants versus those arising from rare genetic variants.

KW - Drosophila sensory bristles

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KW - Single nucleotide polymorphisms (SNPs)

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Patterns of genetic variation in mendelian and complex traits

Abstract

ASJC Scopus subject areas

Keywords

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