Pervaporation as a green drying process for tetrahydrofuran recovery in pharmaceutical synthesis

C. Stewart Slater; Mariano J. Savelski; Timothy M. Moroz; Michael J. Raymond

doi:10.1080/17518253.2011.578590

Pervaporation as a green drying process for tetrahydrofuran recovery in pharmaceutical synthesis

C. Stewart Slater
, Mariano J. Savelski
, Timothy M. Moroz
, Michael J. Raymond

Chemical Engineering

Rowan University

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

The use of pervaporation technology as a green drying process for the recovery and reuse of the solvent, tetrahyrdofuran, in a pharmaceutical synthesis has been evaluated. A case study has been performed on a step in the synthesis of a new oncology drug. Pervaporation has been integrated with a constant-volume distillation process to produce a hybrid system that allows for the recovery and reuse of tetrahydrofuran. An economic and environmental analysis shows that this is an effective technology for this application.

Original language	English (US)
Pages (from-to)	55-64
Number of pages	10
Journal	Green Chemistry Letters and Reviews
Volume	5
Issue number	1
DOIs	https://doi.org/10.1080/17518253.2011.578590
State	Published - Mar 2012

ASJC Scopus subject areas

General Chemistry
Environmental Chemistry

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10.1080/17518253.2011.578590

Cite this

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abstract = "The use of pervaporation technology as a green drying process for the recovery and reuse of the solvent, tetrahyrdofuran, in a pharmaceutical synthesis has been evaluated. A case study has been performed on a step in the synthesis of a new oncology drug. Pervaporation has been integrated with a constant-volume distillation process to produce a hybrid system that allows for the recovery and reuse of tetrahydrofuran. An economic and environmental analysis shows that this is an effective technology for this application.",

author = "\{Stewart Slater\}, C. and Savelski, \{Mariano J.\} and Moroz, \{Timothy M.\} and Raymond, \{Michael J.\}",

note = "Funding Information: Partial support for this research has been provided by a grant from the U.S. Environmental Protection Agency (NP 97257006-0). We appreciate the guidance of Bristol-Myers Squibb scientist and engineers: San Kiang, Thomas La-Porte, Lori Spangler, and Stephan Taylor. We thank the following Rowan University students for their assistance with the studies: Scott Barnes, Anthony Furiato, Kyle Lynch, Timothy Moroz, and Michael Raymond. We appreciate the information provided by Norbert Martin and Eva Maus of Sulzer Chemtech.",

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Pervaporation as a green drying process for tetrahydrofuran recovery in pharmaceutical synthesis

Abstract

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