TY - JOUR
T1 - Pesticide-induced changes in cholinesterase activity and chronic kidney disease of unknown etiology among farmers in Nakhon Ratchasima, Thailand
AU - Sombatsawat, Ekarat
AU - Barr, Dana Boyd
AU - Panuwet, Parinya
AU - Robson, Mark Gregory
AU - Siriwong, Wattasit
N1 - Publisher Copyright: © 2021 Taylor & Francis Group, LLC.
PY - 2021
Y1 - 2021
N2 - Chronic kidney disease of unknown etiology (CKDu) has emerged agricultural population. This study aimed to obtain a prevalence of cholinesterase activity and CKDu, and evaluate factors associated with organophosphate (OP) and carbamate (CA) poisoning and CKDu among farmers in Nakhon Ratchasima province, Thailand. A cross-sectional study was conducted among 58 farmers, with data collected using a structured questionnaire. Blood and urine samples were collected for analysis of erythrocyte acetylcholinesterase (AChE), butyrylcholinesterase (BuChE), serum creatinine (SCr), and urinary creatinine (UCr). Farmers who had CKD without diabetes, hypertension, proteinurea, and other traditional causes were classified as CKDu. The average age (± SD) was 49.22(± 6.87) years. The prevalence of abnormal AChE and BuChE activity levels were 55.17% and 46.55%, respectively. In kidney function, the prevalence of abnormal UCr was 17.24% and CKDu was 24.14%. In adjusted model, the type of pesticide sprayer and personal protective equipment used were significantly associated with CKDu (bivariate analysis, p < 0.05). Using multivariate analysis, OP and CA poisoning were significantly associated with a 4.703-fold higher risk of CKDu (95% CI = 1.020-21.686). Farmers who applied OP and CA pesticides had decreased kidney function. These findings might be beneficial in reducing the adverse effects pesticide exposure and CKDu prevention.
AB - Chronic kidney disease of unknown etiology (CKDu) has emerged agricultural population. This study aimed to obtain a prevalence of cholinesterase activity and CKDu, and evaluate factors associated with organophosphate (OP) and carbamate (CA) poisoning and CKDu among farmers in Nakhon Ratchasima province, Thailand. A cross-sectional study was conducted among 58 farmers, with data collected using a structured questionnaire. Blood and urine samples were collected for analysis of erythrocyte acetylcholinesterase (AChE), butyrylcholinesterase (BuChE), serum creatinine (SCr), and urinary creatinine (UCr). Farmers who had CKD without diabetes, hypertension, proteinurea, and other traditional causes were classified as CKDu. The average age (± SD) was 49.22(± 6.87) years. The prevalence of abnormal AChE and BuChE activity levels were 55.17% and 46.55%, respectively. In kidney function, the prevalence of abnormal UCr was 17.24% and CKDu was 24.14%. In adjusted model, the type of pesticide sprayer and personal protective equipment used were significantly associated with CKDu (bivariate analysis, p < 0.05). Using multivariate analysis, OP and CA poisoning were significantly associated with a 4.703-fold higher risk of CKDu (95% CI = 1.020-21.686). Farmers who applied OP and CA pesticides had decreased kidney function. These findings might be beneficial in reducing the adverse effects pesticide exposure and CKDu prevention.
KW - CKDu
KW - Farmers
KW - cholinesterase
KW - eGFR
KW - pesticide exposure
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U2 - 10.1080/10807039.2021.1944050
DO - 10.1080/10807039.2021.1944050
M3 - Article
SN - 1080-7039
VL - 27
SP - 2038
EP - 2050
JO - Human and Ecological Risk Assessment
JF - Human and Ecological Risk Assessment
IS - 8
ER -