Pharmacokinetic evaluation of cefoperazone in infants

M. Varghese, A. J. Khan, K. Kumar, W. Rosenfeld, H. A. Schaeffer, Hugh Evans

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The pharmacokinetics of cefoperazone were evaluated in 25 infants (mean age, 26 days) after intramuscular and intravenous routes of administration. The levels in blood that were achieved were severalfold higher than those required to inhibit common pathogens. The mean half-life of 240 min was one-half of that observed in 1- to 2-day-old infants but about twice that seen in adults. Further evaluation is needed to study the efficacy of the drug in infants and children.

Original languageEnglish (US)
Pages (from-to)149-150
Number of pages2
JournalAntimicrobial agents and chemotherapy
Volume28
Issue number1
DOIs
StatePublished - Jan 1 1985
Externally publishedYes

Fingerprint

Cefoperazone
Pharmacokinetics
Intravenous Administration
Half-Life
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Pharmacology (medical)
  • Infectious Diseases
  • Pharmacology

Cite this

Varghese, M., Khan, A. J., Kumar, K., Rosenfeld, W., Schaeffer, H. A., & Evans, H. (1985). Pharmacokinetic evaluation of cefoperazone in infants. Antimicrobial agents and chemotherapy, 28(1), 149-150. https://doi.org/10.1128/AAC.28.1.149
Varghese, M. ; Khan, A. J. ; Kumar, K. ; Rosenfeld, W. ; Schaeffer, H. A. ; Evans, Hugh. / Pharmacokinetic evaluation of cefoperazone in infants. In: Antimicrobial agents and chemotherapy. 1985 ; Vol. 28, No. 1. pp. 149-150.
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Varghese, M, Khan, AJ, Kumar, K, Rosenfeld, W, Schaeffer, HA & Evans, H 1985, 'Pharmacokinetic evaluation of cefoperazone in infants', Antimicrobial agents and chemotherapy, vol. 28, no. 1, pp. 149-150. https://doi.org/10.1128/AAC.28.1.149

Pharmacokinetic evaluation of cefoperazone in infants. / Varghese, M.; Khan, A. J.; Kumar, K.; Rosenfeld, W.; Schaeffer, H. A.; Evans, Hugh.

In: Antimicrobial agents and chemotherapy, Vol. 28, No. 1, 01.01.1985, p. 149-150.

Research output: Contribution to journalArticle

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