Photoprotection of Parenteral Nutrition Enhances Advancement of Minimal Enteral Nutrition in Preterm Infants

Minesh Khashu, Adele Harrison, Vikki Lalari, Andrew Gow, Jean Claude Lavoie, Philippe Chessex

Research output: Contribution to journalReview article

22 Scopus citations

Abstract

Background: Light exposure of TPN generates peroxides which induce vasoconstriction. Mesenteric vasoconstriction may affect feeding tolerance. Since photo-protection of TPN decreases peroxide generation, we hypothesized that shielding TPN from light may improve the establishment of minimal enteral nutrition in preterm infants. Methods: Infants were randomized to TPN being light exposed (LE) or protected (LP) from birth. Feeding volumes were monitored through 7 days of life in those initiated on minimal enteral nutrition (MEN). Comparisons between LP and LE were performed by ANOVA. Results: Daily increments and cumulative volumes of enteral feeds (mL/kg birth weight/d) during the first week of life were significantly higher in LP (n = 18) than LE (n = 19). Conclusion: Photo-protection of parenteral nutrition enhances advancement of MEN in preterm infants. Further research is needed to substantiate these findings and determine whether this confers long-term nutritional advantages.

Original languageEnglish (US)
Pages (from-to)139-145
Number of pages7
JournalSeminars in Perinatology
Volume30
Issue number3
DOIs
StatePublished - Jun 1 2006
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynecology
  • Pediatrics, Perinatology, and Child Health

Keywords

  • minimal enteral nutrition
  • newborn
  • parenteral nutrition
  • peroxides
  • photoprotection

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