Phthalate exposure and reproductive hormone concentrations in pregnancy

Sheela Sathyanarayana, Emily Barrett, Samantha Butts, Christina Wang, Shanna Helen Swan

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Some phthalate chemicals can affect hormone physiology in utero, resulting in adverse reproductive health outcomes in animal models. It is unknown whether these exposures are related to circulating maternal hormone concentrations during pregnancy. We used multivariate linear regression to estimate associations between phthalate metabolite concentrations and concurrent serum-free and total testosterone and estradiol (E2) levels in 180 pregnant women in the Study for Future Families. We also examined associations between prenatal serum hormone concentrations and anogenital outcome in infants. All analyses were adjusted for appropriate confounding variables. Total testosterone, free testosterone, and E2 concentrations ranged from 8 to 406 ng/dl, 0.03 to 1.2 ng/dl, and 529 to 40 600 pg/ml respectively. We observed an inverse association between log-sum di-2-ethylhexyl phthalate (DEHP) metabolite concentrations and lower log-total testosterone concentrations (-0.15, 95% CI -0.26, -0.04) and log-free testosterone (-0.15, 95% CI -0.27, -0.03). This relationship persisted regardless of fetal sex. Similarly, we observed an inverse association between log monobutyl phthalate (MBP) concentrations and log-total and -free testosterone concentrations in women carrying male fetuses. Monoethyl phthalate (MEP) concentrations were positively associated with log-total and -free testosterone concentrations in women carrying male fetuses (0.09, 95% CI 0.003, 0.17 and 0.10, 95% CI 0.01, 0.19 respectively). Prenatal hormone concentrations were not significantly associated with infant anogenital outcomes. Our preliminary data suggest that DEHP metabolite, MBP, and MEP exposures during pregnancy are associated with prenatal sex steroid hormone concentrations, but sex steroid hormone concentrations were not associated with infant reproductive outcomes.

Original languageEnglish (US)
Pages (from-to)401-409
Number of pages9
JournalReproduction
Volume147
Issue number4
DOIs
StatePublished - Jan 1 2014

Fingerprint

Testosterone
Hormones
Pregnancy
Gonadal Steroid Hormones
Fetus
Confounding Factors (Epidemiology)
Reproductive Health
phthalic acid
Serum
Pregnant Women
Estradiol
Linear Models
Animal Models
Mothers

All Science Journal Classification (ASJC) codes

  • Endocrinology
  • Obstetrics and Gynecology
  • Cell Biology
  • Reproductive Medicine
  • Embryology

Cite this

Sathyanarayana, Sheela ; Barrett, Emily ; Butts, Samantha ; Wang, Christina ; Swan, Shanna Helen. / Phthalate exposure and reproductive hormone concentrations in pregnancy. In: Reproduction. 2014 ; Vol. 147, No. 4. pp. 401-409.
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Sathyanarayana, S, Barrett, E, Butts, S, Wang, C & Swan, SH 2014, 'Phthalate exposure and reproductive hormone concentrations in pregnancy', Reproduction, vol. 147, no. 4, pp. 401-409. https://doi.org/10.1530/REP-13-0415

Phthalate exposure and reproductive hormone concentrations in pregnancy. / Sathyanarayana, Sheela; Barrett, Emily; Butts, Samantha; Wang, Christina; Swan, Shanna Helen.

In: Reproduction, Vol. 147, No. 4, 01.01.2014, p. 401-409.

Research output: Contribution to journalArticle

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