TY - JOUR
T1 - Physicochemical and toxicological properties of wood smoke particulate matter as a function of wood species and combustion condition
AU - Singh, Dilpreet
AU - Tassew, Dereje Damte
AU - Nelson, Jordan
AU - Chalbot, Marie Cecile G.
AU - Kavouras, Ilias G.
AU - Tesfaigzi, Yohannes
AU - Demokritou, Philip
N1 - Funding Information: This investigation was made possible by grants RO1HL068111 and RO1HL140839 from the US National Institutes of Health . Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the NIH. Additionally, research was supported by the HSPH-NIEHS Nanosafety Center, a member of the Nanotechnology Health Implications Research (NHIR) consortium (NIH grant # U24ES026946 ) and the Rutgers-NIEHS Center for Environmental Exposures and Disease (CEED) (NIH grant # P30ES005022 ). Nanoparticle characterization work was performed in part at the Harvard Center for Nanoscale Systems (CNS), a member of the National Nanotechnology Infrastructure Network (NNIN), which is supported by the US National Science Foundation under NSF award no. ECS-1541959 . The EC-OC and ICP-MS analyses were performed by the Wisconsin State Laboratory of Hygiene based at the University of Wisconsin-Madison. Funding Information: This investigation was made possible by grants RO1HL068111 and RO1HL140839 from the US National Institutes of Health. Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the NIH. Additionally, research was supported by the HSPH-NIEHS Nanosafety Center, a member of the Nanotechnology Health Implications Research (NHIR) consortium (NIH grant # U24ES026946) and the Rutgers-NIEHS Center for Environmental Exposures and Disease (CEED) (NIH grant # P30ES005022). Nanoparticle characterization work was performed in part at the Harvard Center for Nanoscale Systems (CNS), a member of the National Nanotechnology Infrastructure Network (NNIN), which is supported by the US National Science Foundation under NSF award no. ECS-1541959. The EC-OC and ICP-MS analyses were performed by the Wisconsin State Laboratory of Hygiene based at the University of Wisconsin-Madison. Wood burning releases a complex mixture of hundreds of semi-volatile/volatile organic compounds and has both acute and chronic effects on pulmonary health. The WHO estimates nearly 4 million people die prematurely each year from diseases caused by biomass burning. This work addresses a critical knowledge gap on the link between woodburning parameters (wood type and combustion condition) and human health implications by examining the effect of wood smoke on a biomarker of mucin gene expression implicated in mucus-related respiratory diseases. Such data will enable risk assessors to provide operational recommendations on domestic wood combustion to protect health of vulnerable populations. Publisher Copyright: © 2022 Elsevier B.V.
PY - 2023/1/5
Y1 - 2023/1/5
N2 - Wood burning is a major source of ambient particulate matter (PM) and has been epidemiologically linked to adverse pulmonary health effects, however the impact of fuel and burning conditions on PM properties has not been investigated systematically. Here, we employed our recently developed integrated methodology to characterize the physicochemical and biological properties of emitted PM as a function of three common hardwoods (oak, cherry, mesquite) and three representative combustion conditions (flaming, smoldering, incomplete). Differences in PM and off-gas emissions (aerosol number/mass concentrations; carbon monoxide; volatile organic compounds) as well as inorganic elemental composition and organic carbon functional content of PM0.1 were noted between wood types and combustion conditions, although the combustion scenario exerted a stronger influence on the emission profile. More importantly, flaming combustion PM0.1 from all hardwoods significantly stimulated the promoter activity of Sterile Alpha Motif (SAM) pointed domain containing ETS (E-twenty-six) Transcription Factor (SPDEF) in human embryonic kidney 293 (HEK-293 T) cells, a biomarker for mucin gene expression associated with mucus production in pulmonary diseases. However, no bioactivity was observed for smoldering and incomplete combustion, which was likely driven by differences in the organic composition of PM0.1. Detailed chemical speciation of organic components of wood smoke is warranted to identify the individual compounds that drive specific biological responses.
AB - Wood burning is a major source of ambient particulate matter (PM) and has been epidemiologically linked to adverse pulmonary health effects, however the impact of fuel and burning conditions on PM properties has not been investigated systematically. Here, we employed our recently developed integrated methodology to characterize the physicochemical and biological properties of emitted PM as a function of three common hardwoods (oak, cherry, mesquite) and three representative combustion conditions (flaming, smoldering, incomplete). Differences in PM and off-gas emissions (aerosol number/mass concentrations; carbon monoxide; volatile organic compounds) as well as inorganic elemental composition and organic carbon functional content of PM0.1 were noted between wood types and combustion conditions, although the combustion scenario exerted a stronger influence on the emission profile. More importantly, flaming combustion PM0.1 from all hardwoods significantly stimulated the promoter activity of Sterile Alpha Motif (SAM) pointed domain containing ETS (E-twenty-six) Transcription Factor (SPDEF) in human embryonic kidney 293 (HEK-293 T) cells, a biomarker for mucin gene expression associated with mucus production in pulmonary diseases. However, no bioactivity was observed for smoldering and incomplete combustion, which was likely driven by differences in the organic composition of PM0.1. Detailed chemical speciation of organic components of wood smoke is warranted to identify the individual compounds that drive specific biological responses.
KW - Chemical composition
KW - Combustion conditions
KW - Hardwoods
KW - Mucus production
KW - Particulate matter
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U2 - https://doi.org/10.1016/j.jhazmat.2022.129874
DO - https://doi.org/10.1016/j.jhazmat.2022.129874
M3 - Article
C2 - 36084462
SN - 0304-3894
VL - 441
JO - Journal of Hazardous Materials
JF - Journal of Hazardous Materials
M1 - 129874
ER -