Pioneer axon guidance by UNC-129, a C. elegans TGF-β

Antonio Colavita, Srikant Krishna, Hong Zheng, Richard W. Padgett, Joseph C. Culotti

Research output: Contribution to journalArticlepeer-review

188 Scopus citations


The unc-129 gene, like the unc-6 netrin gene, is required to guide pioneer motoraxons along the dorsoventral axis of Caenorhabditis elegans. unc-129 encodes a member of the transforming growth factor-β (TGF-β) superfamily of secreted signaling molecules and is expressed in dorsal, but not ventral, rows of body wall muscles. Ectopic expression of UNC-129 from ventral body wall muscle disrupts growth cone and cell migrations that normally occur along the dorsoventral axis. Thus, UNC-129 mediates expression of dorsoventral polarity information required for axon guidance and guided cell migrations in C. elegans.

Original languageAmerican English
Pages (from-to)706-709
Number of pages4
Issue number5377
StatePublished - Jul 31 1998

ASJC Scopus subject areas

  • General


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