Pioneer axon guidance by UNC-129, a C. elegans TGF-β

TY - JOUR

T1 - Pioneer axon guidance by UNC-129, a C. elegans TGF-β

AU - Colavita, Antonio

AU - Krishna, Srikant

AU - Zheng, Hong

AU - Padgett, Richard W.

AU - Culotti, Joseph C.

PY - 1998/7/31

Y1 - 1998/7/31

N2 - The unc-129 gene, like the unc-6 netrin gene, is required to guide pioneer motoraxons along the dorsoventral axis of Caenorhabditis elegans. unc-129 encodes a member of the transforming growth factor-β (TGF-β) superfamily of secreted signaling molecules and is expressed in dorsal, but not ventral, rows of body wall muscles. Ectopic expression of UNC-129 from ventral body wall muscle disrupts growth cone and cell migrations that normally occur along the dorsoventral axis. Thus, UNC-129 mediates expression of dorsoventral polarity information required for axon guidance and guided cell migrations in C. elegans.

AB - The unc-129 gene, like the unc-6 netrin gene, is required to guide pioneer motoraxons along the dorsoventral axis of Caenorhabditis elegans. unc-129 encodes a member of the transforming growth factor-β (TGF-β) superfamily of secreted signaling molecules and is expressed in dorsal, but not ventral, rows of body wall muscles. Ectopic expression of UNC-129 from ventral body wall muscle disrupts growth cone and cell migrations that normally occur along the dorsoventral axis. Thus, UNC-129 mediates expression of dorsoventral polarity information required for axon guidance and guided cell migrations in C. elegans.

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M3 - Article

C2 - 9685266

SN - 0036-8075

VL - 281

SP - 706

EP - 709

JO - Science (New York, N.Y.)

JF - Science (New York, N.Y.)

IS - 5377

ER -