Abstract

Polycomb Group Proteins is a comprehensive volume detailing the mechanisms that are key to the management of genome function in many different contexts, from embryonic stem cells to terminal differentiation. The book discusses the regulation of cell lineages, cell proliferation, apoptosis, X chromosome inactivation, and most major genome programming choices. In the last few years, the biochemical understanding of PRC1-type complexes has greatly expanded in terms of the number of components involved and the intricacies of their interactions. The functionalities of these various complexes and their components are not all well understood, but recent work has shown an important division of labor and roles in the recruitment of stable binding in the ability to lay the groundwork of histone modifications and in the epigenetic maintenance of repressed states. In an effort to provide clarity in this topical research area, the book provides a cluster of chapters that deal with variant PRC1 complexes, their taxonomy, their components, their interactions, and what is known of their functions. Provides topical coverage on accessory components that are known to be involved in PcG recruitment in Drosophila and their less understood role in mammals Includes dedicated sections on PRC1 complexes and PRC2 complexes for quick reference Features the role of RNA molecules in different aspects of Polycomb proteins involvement in epigenetic regulation, beginning with the key role of the Xist RNA in recruiting and spreading PcG complexes on the inactive X chromosome.

Original languageEnglish (US)
PublisherElsevier Inc.
Number of pages354
ISBN (Electronic)9780128098226
ISBN (Print)9780128097373
StatePublished - Jan 5 2017
EventPolycomb Group Proteins -
Duration: Jan 5 2017 → …

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Polycomb-Group Proteins
Chromosomes
Epigenomics
Histone Code
Genes
Genome
RNA
X Chromosome Inactivation
Mammals
Cell proliferation
Accessories
X Chromosome
Cell Lineage
Taxonomies
Embryonic Stem Cells
Stem cells
Histones
Drosophila
Cells
Maintenance

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Pirrotta, V. (2017). Polycomb Group Proteins. Elsevier Inc.
Pirrotta, Vincenzo. / Polycomb Group Proteins. Elsevier Inc., 2017. 354 p.
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Polycomb Group Proteins. / Pirrotta, Vincenzo.

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Pirrotta V. Polycomb Group Proteins. Elsevier Inc., 2017. 354 p.