Pooled Analysis of Alcohol Dehydrogenase Genotypes and Head and Neck Cancer: A HuGE Review

Paul Brennan, Sarah Lewis, Mia Hashibe, Douglas A. Bell, Paolo Boffetta, Christine Bouchardy, Neil Caporaso, Chu Chen, Christiane Coutelle, Scott R. Diehl, Richard B. Hayes, Andrew F. Olshan, Stephen M. Schwartzs, Erich M. Sturgis, Qingyi Wei, Athanasios I. Zavras, Simone Benhamou

Research output: Contribution to journalReview articlepeer-review

195 Scopus citations


Possession of the fast metabolizing alleles for alcohol dehydrogenase (ADH), ADH1B* 2 and ADH1C* 1, and the null allele for aldehyde dehydrogenase (ALDH), ALDH2± 2, results in increased acetylaldehyde levels and is hypothesized to increase the risk of head and neck cancer. To examine this association, the authors undertook a Human Genome Epidemiology review on these three genes and a pooled analysis of published studies on ADH1C. The majority of Asians had the fast ADH1B* 2 and ADH1C* 1 alleles, while the majority of Caucasians had the slow ADH1B* 1/1 and ADH1C* 1/2 genotypes. The ALDH2* 2 null allele was frequently observed among Asians, though it was rarely observed in other populations. In a pooled analysis of data from seven case-control studies with a total of 1,325 cases and 1,760 controls, an increased risk of head and neck cancer was not observed for the ADH1C* 1/2 genotype (odds ratio = 1.00, 95% confidence interval: 0.81, 1.23) or the ADH1C* 1/1 genotype (odds ratio = 1.14, 95% confidence interval: 0.92, 1.41). Increased relative risks of head and neck cancer were reported for the ADH1B* 1/1 and ALDH2* 1/2 genotypes in several studies. Recommendations for future studies include larger sample sizes and incorporation of relevant ADH and ALDH genes simultaneously, as well as other genes. These considerations suggest the potential for the organization of a consortium of investigators conducting studies in this field.

Original languageAmerican English
Pages (from-to)1-16
Number of pages16
JournalAmerican journal of epidemiology
Issue number1
StatePublished - Jan 1 2004

ASJC Scopus subject areas

  • General Medicine


  • ADH1B
  • ADH1C
  • ALDH2
  • Alcohol dehydrogenase
  • Aldehyde dehydrogenase
  • Epidemiology
  • Genetics
  • Head and neck neoplasms

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