Posttranslationally modified microcins

O. A. Pavlova, K. V. Severinov

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations


Microcins are antibacterial compounds that are encoded in the bacterial genome and synthesized via ribosomal translation. Microcins play an important role in microbial ecology and are promising as antibiotics. To exert their effect, most microcins are incorporated in the membrane of sensitive cells to increase its permeability. The review considers the known classes of posttranslationally modified microcins. These microcins are unusual in structure and inhibit the grown of sensitive cells by entering their cytoplasm and affecting intracellular targets, such as DNA gyrase, DNA-dependent RNA polymerase, and aspartyl-tRNA synthase.

Original languageEnglish (US)
Pages (from-to)1636-1646
Number of pages11
Issue number12
StatePublished - Dec 2006

ASJC Scopus subject areas

  • Medicine(all)


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