Prazosin and phentolamine: Comparative cardiovascular and autonomic profiles

TY - JOUR

T1 - Prazosin and phentolamine

T2 - Comparative cardiovascular and autonomic profiles

AU - Commarato, M. A.

AU - Langley, A. E.

AU - Dugan, D. H.

AU - Lattime, E. C.

AU - Smith, R. D.

AU - Tessman, D. K.

AU - Kaplan, H. R.

PY - 1978

Y1 - 1978

N2 - The general cardiovascular-autonomic profiles of prazosin (PR) and phentolamine (PH) were compared. Antihypertensive activity was evaluated in conscious spontaneously hypertensive rats (SHR) using single oral doses of either agent. PR (0.01 -30 mg/kg, p.o.) caused dose-dependent reductions in mean aortic blood pressure (BP) (δ -13± 5 to δ -61± 3 mm Hg). PH (1-100 mg/kg, p.o.; δ -11 ±2 to δ -52 ± 9 mm Hg) was much less potent than PR and required a dose of at least 1.0 mg/kg to produce a significant BP reduction; their log-dose response curves were not parallel. Both agents caused a tachycardia commensurate with their BP reductions. PH had a shorter duration of action than PR and with both agents duration was dose related. PR and PH but not minoxidii interfered with the usual compensatory reflex BP response to vertical tilt in conscious SHR; however, the

AB - The general cardiovascular-autonomic profiles of prazosin (PR) and phentolamine (PH) were compared. Antihypertensive activity was evaluated in conscious spontaneously hypertensive rats (SHR) using single oral doses of either agent. PR (0.01 -30 mg/kg, p.o.) caused dose-dependent reductions in mean aortic blood pressure (BP) (δ -13± 5 to δ -61± 3 mm Hg). PH (1-100 mg/kg, p.o.; δ -11 ±2 to δ -52 ± 9 mm Hg) was much less potent than PR and required a dose of at least 1.0 mg/kg to produce a significant BP reduction; their log-dose response curves were not parallel. Both agents caused a tachycardia commensurate with their BP reductions. PH had a shorter duration of action than PR and with both agents duration was dose related. PR and PH but not minoxidii interfered with the usual compensatory reflex BP response to vertical tilt in conscious SHR; however, the

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U2 - https://doi.org/10.3109/10641967809068604

DO - https://doi.org/10.3109/10641967809068604

M3 - Article

C2 - 39713

SN - 1064-1963

VL - 1

SP - 191

EP - 217

JO - Clinical and Experimental Hypertension

JF - Clinical and Experimental Hypertension

IS - 2

ER -