Predatory Bacteria: A Potential Ally against Multidrug-Resistant Gram-Negative Pathogens

Daniel E. Kadouri, Kevin To, Robert M.Q. Shanks, Yohei Doi

Research output: Contribution to journalArticlepeer-review

101 Scopus citations


Multidrug-resistant (MDR) Gram-negative bacteria have emerged as a serious threat to human and animal health. Bdellovibrio spp. and Micavibrio spp. are Gram-negative bacteria that prey on other Gram-negative bacteria. In this study, the ability of Bdellovibrio bacteriovorus and Micavibrio aeruginosavorus to prey on MDR Gram-negative clinical strains was examined. Although the potential use of predatory bacteria to attack MDR pathogens has been suggested, the data supporting these claims is lacking. By conducting predation experiments we have established that predatory bacteria have the capacity to attack clinical strains of a variety of ß-lactamase-producing, MDR Gram-negative bacteria. Our observations indicate that predatory bacteria maintained their ability to prey on MDR bacteria regardless of their antimicrobial resistance, hence, might be used as therapeutic agents where other antimicrobial drugs fail.

Original languageEnglish (US)
Article numbere63397
JournalPloS one
Issue number5
StatePublished - May 1 2013

All Science Journal Classification (ASJC) codes

  • Agricultural and Biological Sciences(all)
  • General
  • Biochemistry, Genetics and Molecular Biology(all)


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