Prenylated Coumaric Acids fromArtemisia scopariaBeneficially Modulate Adipogenesis

David Ribnicky, Seon Beom Kim, Alexander Poulev, Yang Wang, Anik Boudreau, Ilya Raskin, Jonathan Bisson, G. Joseph Ray, Shao Nong Chen, Allison Richard, Jacqueline M. Stephens, Guido F. Pauli

Research output: Contribution to journalReview articlepeer-review


Two new diprenylated coumaric acid isomers (1aand1b) and two known congeners, capillartemisin A (2) and B (3), were isolated fromArtemisia scopariaas bioactive markers using bioactivity-guided HPLC fractionation. Their structures were determined by spectroscopic means, including 1D and 2D NMR methods and LC-MS, with their purity assessed by 1D1H pure shift qNMR spectroscopic analysis. The bioactivity of compounds was evaluated by enhanced accumulation of lipids, as measured using Oil Red O staining, and by increased expression of several adipocyte marker genes, including adiponectin in 3T3-L1 adipocytes relative to untreated negative controls. Compared to the plant’s 80% EtOH extract, these purified compounds showed significant but still weaker inhibition of TNFα-induced lipolysis in 3T3-L1 adipocytes. This suggests that additional bioactive substances are responsible for the multiple metabolically favorable effects on adipocytes observed withArtemisia scopariaextract.

Original languageAmerican English
Pages (from-to)1078-1086
Number of pages9
JournalJournal of Natural Products
Issue number4
StatePublished - Apr 23 2021

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry


Dive into the research topics of 'Prenylated Coumaric Acids fromArtemisia scopariaBeneficially Modulate Adipogenesis'. Together they form a unique fingerprint.

Cite this