Presession noise increases sensitivity to chlordiazepoxide's discriminative stimulus in pigeons

Arthur Tomie, Penny L. Shultz, Nicole M. Quartarolo, Carlos Cunha

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

1. Pigeons were trained to discriminate chlordiazepoxide (CDP) from saline using two-key food reinforced drug discrimination procedures. Discriminative control by CDP was maintained despite extended training with vehicle-like doses of CDP, by using a modified 'fading' procedure that provided for a mixture of drug discrimination training sessions preceded by an i.m. injection of either 8.0 mg/kg CDP, or a lower training dose of CDP (4.0, 2.8, 2.0, 1.4, 1.0, 0.7, or 0.5 mg/kg CDP), or saline. The lower training dose was decreased across blocks of sessions. 2. Four lower training doses (1.4, 1.0, 0.7, and 0.5 mg/kg CDP) were retrained, with 10 min of 98 dB of noise administered 75 min prior to each drug discrimination training session. Presession exposure to noise increased percent CDP-appropriate choices for each of the four lower training doses by 15-20% over those obtained previously. 3. It is concluded that brief presession exposure to loud noise increases sensitivity to the discriminative stimulus effects of low training doses of CDP.

Original languageEnglish (US)
Pages (from-to)1155-1168
Number of pages14
JournalProgress in Neuro-Psychopharmacology and Biological Psychiatry
Volume21
Issue number7
DOIs
StatePublished - Oct 1997

ASJC Scopus subject areas

  • Pharmacology
  • Biological Psychiatry

Keywords

  • Chlordiazepoxide
  • Drug discrimination
  • Fading
  • Noise
  • Pigeons
  • Sensitivity
  • Sensitization
  • Stress

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