TY - JOUR
T1 - Presession noise increases sensitivity to chlordiazepoxide's discriminative stimulus in pigeons
AU - Tomie, Arthur
AU - Shultz, Penny L.
AU - Quartarolo, Nicole M.
AU - Cunha, Carlos
PY - 1997/10
Y1 - 1997/10
N2 - 1. Pigeons were trained to discriminate chlordiazepoxide (CDP) from saline using two-key food reinforced drug discrimination procedures. Discriminative control by CDP was maintained despite extended training with vehicle-like doses of CDP, by using a modified 'fading' procedure that provided for a mixture of drug discrimination training sessions preceded by an i.m. injection of either 8.0 mg/kg CDP, or a lower training dose of CDP (4.0, 2.8, 2.0, 1.4, 1.0, 0.7, or 0.5 mg/kg CDP), or saline. The lower training dose was decreased across blocks of sessions. 2. Four lower training doses (1.4, 1.0, 0.7, and 0.5 mg/kg CDP) were retrained, with 10 min of 98 dB of noise administered 75 min prior to each drug discrimination training session. Presession exposure to noise increased percent CDP-appropriate choices for each of the four lower training doses by 15-20% over those obtained previously. 3. It is concluded that brief presession exposure to loud noise increases sensitivity to the discriminative stimulus effects of low training doses of CDP.
AB - 1. Pigeons were trained to discriminate chlordiazepoxide (CDP) from saline using two-key food reinforced drug discrimination procedures. Discriminative control by CDP was maintained despite extended training with vehicle-like doses of CDP, by using a modified 'fading' procedure that provided for a mixture of drug discrimination training sessions preceded by an i.m. injection of either 8.0 mg/kg CDP, or a lower training dose of CDP (4.0, 2.8, 2.0, 1.4, 1.0, 0.7, or 0.5 mg/kg CDP), or saline. The lower training dose was decreased across blocks of sessions. 2. Four lower training doses (1.4, 1.0, 0.7, and 0.5 mg/kg CDP) were retrained, with 10 min of 98 dB of noise administered 75 min prior to each drug discrimination training session. Presession exposure to noise increased percent CDP-appropriate choices for each of the four lower training doses by 15-20% over those obtained previously. 3. It is concluded that brief presession exposure to loud noise increases sensitivity to the discriminative stimulus effects of low training doses of CDP.
KW - Chlordiazepoxide
KW - Drug discrimination
KW - Fading
KW - Noise
KW - Pigeons
KW - Sensitivity
KW - Sensitization
KW - Stress
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U2 - https://doi.org/10.1016/S0278-5846(97)00107-3
DO - https://doi.org/10.1016/S0278-5846(97)00107-3
M3 - Article
C2 - 9421828
VL - 21
SP - 1155
EP - 1168
JO - Progress in Neuro-Psychopharmacology and Biological Psychiatry
JF - Progress in Neuro-Psychopharmacology and Biological Psychiatry
SN - 0278-5846
IS - 7
ER -