Two hundred twenty‐four sera were collected from 34 HIV‐1 infected patients during an observation period of up to 4.5 years (109 patient years of observation). The sera were tested for the presence of antibodies against the HIV‐1 virion infectivity factor (vif) protein. Thirty sera from 6 HIV‐1 seronegative individuals served as negative controls. The sera were immunoblotted against a recombinant, prokaryotically expressed vif protein. The prevalence of anti‐vif antibodies increased significantly with progression of the disease from 18% to 81% (P < 0.0001) which suggests a possible role of vif in HIV‐1 replication and pathogenicity.
All Science Journal Classification (ASJC) codes
- Infectious Diseases
- anti‐vif antibodies
- prospective study
- regulatory proteins