Projections from the paraventricular nucleus to the zona externa of the median eminence of the rhesus monkey

An immunohistochemical study

J. Lobo Antunes, Peter Carmel, Earl A. Zimmerman

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

Immunoperoxidase techniques and light microscopy were used to investigate the origin of the fibers containing vasopressin, oxytocin and related neurophysins (neurohypophyseal peptides), in the zona externa of the median eminence of the rhesus monkey. Unilateral lesions were produced in the paraventricular nucleus using a modified Halasz-type knife. Complete destruction of the paraventricular nucleus resulted in a total depletion of all four neurohpophyseal peptides in the ipsilateral zona externa of the median eminence. Partial lesions of different segments of the paraventricular nucleus resulted in depletion in different parts of the zona externa. These observations indicate that the paraventricular nucleus in the source of vasopressin, oxytocin and neurophysin in axons which end in the zona externa of the median eminence. These projections are strictly ipsilateral and arranged topographically, so that the more caudal paraventricular neurons project to the dorsal part of the zona externa and the rostral ones to the ventral segment. The supraoptic nucleus does not appear to project to the zona externa, and sends the great majority of its fibers to the neurohypophysis.

Original languageEnglish (US)
Pages (from-to)1-10
Number of pages10
JournalBrain research
Volume137
Issue number1
DOIs
StatePublished - Nov 25 1977
Externally publishedYes

Fingerprint

Median Eminence
Paraventricular Hypothalamic Nucleus
Herpes Zoster
Macaca mulatta
Neurophysins
Oxytocin
Vasopressins
Posterior Pituitary Hormones
Posterior Pituitary Gland
Supraoptic Nucleus
Immunoenzyme Techniques
Axons
Microscopy
Neurons
Light
Peptides

All Science Journal Classification (ASJC) codes

  • Clinical Neurology
  • Molecular Biology
  • Neuroscience(all)
  • Developmental Biology

Cite this

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abstract = "Immunoperoxidase techniques and light microscopy were used to investigate the origin of the fibers containing vasopressin, oxytocin and related neurophysins (neurohypophyseal peptides), in the zona externa of the median eminence of the rhesus monkey. Unilateral lesions were produced in the paraventricular nucleus using a modified Halasz-type knife. Complete destruction of the paraventricular nucleus resulted in a total depletion of all four neurohpophyseal peptides in the ipsilateral zona externa of the median eminence. Partial lesions of different segments of the paraventricular nucleus resulted in depletion in different parts of the zona externa. These observations indicate that the paraventricular nucleus in the source of vasopressin, oxytocin and neurophysin in axons which end in the zona externa of the median eminence. These projections are strictly ipsilateral and arranged topographically, so that the more caudal paraventricular neurons project to the dorsal part of the zona externa and the rostral ones to the ventral segment. The supraoptic nucleus does not appear to project to the zona externa, and sends the great majority of its fibers to the neurohypophysis.",
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Projections from the paraventricular nucleus to the zona externa of the median eminence of the rhesus monkey : An immunohistochemical study. / Lobo Antunes, J.; Carmel, Peter; Zimmerman, Earl A.

In: Brain research, Vol. 137, No. 1, 25.11.1977, p. 1-10.

Research output: Contribution to journalArticle

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