Prophylactic effect of flavanol rich preparation metabolites in promoting resilience to a mouse model of social stress

Jun Wang, Danyue Zhao, Simoni Tiano, Adelaida Esteban-Fernández, Bo Yuan, Chad Smith, Justin Brathwaite, Zahra Jlayer, Qingli Wu, James E. Simon, Kyle J. Trageser, Giulio M. Pasinetti

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Major depressive disorder (MDD) is a leading cause of disability, and there is an urgent need for new therapeutics. Stress-mediated induction of pro-inflammation in the periphery contributes to depression-like behaviors both in humans and in experimental models. Inflammatory cytokine interleukin-6 (IL-6) has emerged as a potential therapeutic target. Our studies demonstrated that metabolism of flavanol rich cocoa preparation (FRP) led to the accumulation of select phenolic acids that may contribute to its anti-inflammatory activity. Using a repeated social defeat stress (RSDS) model of depression, we showed that oral administration of FRP attenuates susceptibility to RSDS-mediated depression, supporting the further development of FRP as a novel therapeutic for the treatment of stress disorders and anxiety in humans.

Original languageEnglish (US)
Article number183
JournalTranslational psychiatry
Volume10
Issue number1
DOIs
StatePublished - Dec 1 2020
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience
  • Biological Psychiatry

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