Protein turnover plays a key role in aging

Alexey Ryazanov, Bradley S. Nefsky

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

Although the molecular mechanism of aging is unknown, a progressive increase with age in the concentration of damaged macromolecules, especially proteins, is likely to play a central role in senescent decline. In this paper, we discuss evidence that the progressive decrease in protein synthesis and turnover can be the primary cause of the increase in the concentration of damaged proteins with age. Conversely, protein damage itself is likely to be the cause of the decrease in protein turnover. This could establish a positive feedback loop where the increase in protein damage decreases the protein turnover rate, leading to a further increase in the concentration of damaged proteins. The establishment of such a feedback loop should result in an exponential increase in the amount of protein damage - a protein damage catastrophe - that could be the basis of the general deterioration observed in senescent organisms.

Original languageEnglish (US)
Pages (from-to)207-213
Number of pages7
JournalMechanisms of Ageing and Development
Volume123
Issue number2-3
DOIs
StatePublished - Jan 1 2002

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Proteins

All Science Journal Classification (ASJC) codes

  • Aging
  • Developmental Biology

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Ryazanov, Alexey ; Nefsky, Bradley S. / Protein turnover plays a key role in aging. In: Mechanisms of Ageing and Development. 2002 ; Vol. 123, No. 2-3. pp. 207-213.
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Protein turnover plays a key role in aging. / Ryazanov, Alexey; Nefsky, Bradley S.

In: Mechanisms of Ageing and Development, Vol. 123, No. 2-3, 01.01.2002, p. 207-213.

Research output: Contribution to journalArticle

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