Pulmonary Manifestations of Genetic Disorders in Children

Beth A. Pletcher, Nelson L. Turcios

Research output: Contribution to journalReview articlepeer-review


Congenital bronchopulmonary malformations are relatively common and arise during various periods of morphogenesis. Although some are isolated or sporadic occurrences, others may result from single gene mutations or cytogenetic imbalances. Single gene mutations have been identified, which are etiologically related to primary pulmonary hypoplasia, lung segmentation defects as well as pulmonary vascular and lymphatic lesions. Functional defects in cystic fibrosis, primary ciliary dyskinesias, alpha-1-antitrypsin deficiency, and surfactant proteins caused by gene mutations may result in progressive pulmonary disease. This article provides an overview of pediatric pulmonary disease from a genetic perspective.

Original languageEnglish (US)
Pages (from-to)1-24
Number of pages24
JournalPediatric Clinics of North America
Issue number1
StatePublished - Feb 2021

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


  • Congenital lung malformations
  • Pediatric pulmonary disorders
  • Pulmonary genetics


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