Pulmonary phenotypes of bronchopulmonary dysplasia in the preterm infant

Margaret Gilfillan; Vineet Bhandari

doi:10.1016/j.semperi.2023.151810

Pulmonary phenotypes of bronchopulmonary dysplasia in the preterm infant

Margaret Gilfillan
, Vineet Bhandari

CMSRU Faculty Affairs

Rowan University

Research output: Contribution to journal › Article › peer-review

Abstract

Bronchopulmonary dysplasia (BPD) remains the most common complication of premature birth, imposing a significant and potentially life-long burden on patients and their families. Despite advances in our understanding of the mechanisms that contribute to patterns of lung injury and dysfunctional repair, current therapeutic strategies remain non-specific with limited success. Contemporary definitions of BPD continue to rely on clinician prescribed respiratory support requirements at specific time points. While these criteria may be helpful in broadly identifying infants at higher risk of adverse outcomes, they do not offer any precise information regarding the degree to which each compartment of the lung is affected. In this review we will outline the different pulmonary phenotypes of BPD and discuss important features in the pathogenesis, clinical presentation, and management of these frequently overlapping scenarios.

Original language	English (US)
Article number	151810
Journal	Seminars in Perinatology
Volume	47
Issue number	6
DOIs	https://doi.org/10.1016/j.semperi.2023.151810
State	Published - Oct 2023

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Obstetrics and Gynecology

Access to Document

10.1016/j.semperi.2023.151810

Cite this

@article{32001e31cfb4462cbc527318bbdda6cc,

title = "Pulmonary phenotypes of bronchopulmonary dysplasia in the preterm infant",

abstract = "Bronchopulmonary dysplasia (BPD) remains the most common complication of premature birth, imposing a significant and potentially life-long burden on patients and their families. Despite advances in our understanding of the mechanisms that contribute to patterns of lung injury and dysfunctional repair, current therapeutic strategies remain non-specific with limited success. Contemporary definitions of BPD continue to rely on clinician prescribed respiratory support requirements at specific time points. While these criteria may be helpful in broadly identifying infants at higher risk of adverse outcomes, they do not offer any precise information regarding the degree to which each compartment of the lung is affected. In this review we will outline the different pulmonary phenotypes of BPD and discuss important features in the pathogenesis, clinical presentation, and management of these frequently overlapping scenarios.",

author = "Margaret Gilfillan and Vineet Bhandari",

note = "Publisher Copyright: {\textcopyright} 2023 Elsevier Inc.",

year = "2023",

month = oct,

doi = "10.1016/j.semperi.2023.151810",

language = "English (US)",

volume = "47",

journal = "Seminars in Perinatology",

issn = "0146-0005",

publisher = "W.B. Saunders",

number = "6",

}

TY - JOUR

T1 - Pulmonary phenotypes of bronchopulmonary dysplasia in the preterm infant

AU - Gilfillan, Margaret

AU - Bhandari, Vineet

PY - 2023/10

Y1 - 2023/10

N2 - Bronchopulmonary dysplasia (BPD) remains the most common complication of premature birth, imposing a significant and potentially life-long burden on patients and their families. Despite advances in our understanding of the mechanisms that contribute to patterns of lung injury and dysfunctional repair, current therapeutic strategies remain non-specific with limited success. Contemporary definitions of BPD continue to rely on clinician prescribed respiratory support requirements at specific time points. While these criteria may be helpful in broadly identifying infants at higher risk of adverse outcomes, they do not offer any precise information regarding the degree to which each compartment of the lung is affected. In this review we will outline the different pulmonary phenotypes of BPD and discuss important features in the pathogenesis, clinical presentation, and management of these frequently overlapping scenarios.

AB - Bronchopulmonary dysplasia (BPD) remains the most common complication of premature birth, imposing a significant and potentially life-long burden on patients and their families. Despite advances in our understanding of the mechanisms that contribute to patterns of lung injury and dysfunctional repair, current therapeutic strategies remain non-specific with limited success. Contemporary definitions of BPD continue to rely on clinician prescribed respiratory support requirements at specific time points. While these criteria may be helpful in broadly identifying infants at higher risk of adverse outcomes, they do not offer any precise information regarding the degree to which each compartment of the lung is affected. In this review we will outline the different pulmonary phenotypes of BPD and discuss important features in the pathogenesis, clinical presentation, and management of these frequently overlapping scenarios.

UR - https://www.scopus.com/pages/publications/85172225805

UR - https://www.scopus.com/pages/publications/85172225805#tab=citedBy

U2 - 10.1016/j.semperi.2023.151810

DO - 10.1016/j.semperi.2023.151810

M3 - Article

C2 - 37775367

SN - 0146-0005

VL - 47

JO - Seminars in Perinatology

JF - Seminars in Perinatology

IS - 6

M1 - 151810

ER -

Pulmonary phenotypes of bronchopulmonary dysplasia in the preterm infant

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this