TY - JOUR
T1 - Quality of life, mood, and sexual function
T2 - A path analytic model of treatment effects in men with erectile dysfunction and depressive symptoms
AU - Rosen, R. C.
AU - Seidman, S. N.
AU - Menza, M. A.
AU - Shabsigh, R.
AU - Roose, S. P.
AU - Tseng, L. J.
AU - Orazem, J.
AU - Siegel, R. L.
PY - 2004/8
Y1 - 2004/8
N2 - Erectile dysfunction (ED) is commonly associated with depressed mood and diminished quality of life (QoL), but few studies have investigated the causal associations involved. Therefore, we evaluated the correlation between several measures of mood, QoL, and sexual function in a retrospective analysis of a sample of depressed men (n = 152), with ED enrolled in a clinical trial of sildenafil citrate (VIAGRA®). Strong correlations were observed at baseline among measures of erectile function (EF), mood, and overall QoL. Significant treatment effects were observed on all three domains, with significant interactions between changes in mood and QoL. Based on multiple regression and path analysis, a model was developed in which EF changes were associated with improved mood and quality of sexual life, which resulted in improved partner satisfaction, family life, and overall life satisfaction. These data suggest that QoL changes associated with ED therapy may be mediated by changes in sexual function, mood, and family relationships.
AB - Erectile dysfunction (ED) is commonly associated with depressed mood and diminished quality of life (QoL), but few studies have investigated the causal associations involved. Therefore, we evaluated the correlation between several measures of mood, QoL, and sexual function in a retrospective analysis of a sample of depressed men (n = 152), with ED enrolled in a clinical trial of sildenafil citrate (VIAGRA®). Strong correlations were observed at baseline among measures of erectile function (EF), mood, and overall QoL. Significant treatment effects were observed on all three domains, with significant interactions between changes in mood and QoL. Based on multiple regression and path analysis, a model was developed in which EF changes were associated with improved mood and quality of sexual life, which resulted in improved partner satisfaction, family life, and overall life satisfaction. These data suggest that QoL changes associated with ED therapy may be mediated by changes in sexual function, mood, and family relationships.
KW - Oral vasoactive agents
KW - Pharmacologic studies in sexual function
UR - http://www.scopus.com/inward/record.url?scp=4644359937&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=4644359937&partnerID=8YFLogxK
U2 - https://doi.org/10.1038/sj.ijir.3901197
DO - https://doi.org/10.1038/sj.ijir.3901197
M3 - Article
C2 - 14961048
SN - 0955-9930
VL - 16
SP - 334
EP - 340
JO - International Journal of Impotence Research
JF - International Journal of Impotence Research
IS - 4
ER -