Quality of life of men treated for localized prostate cancer: Outcomes at 6 and 12 months

TY - JOUR

T1 - Quality of life of men treated for localized prostate cancer

T2 - Outcomes at 6 and 12 months

AU - Lev, Elise L.

AU - Eller, Lucille Sanzero

AU - Gejerman, Glen

AU - Kolassa, John

AU - Colella, Joan

AU - Pezzino, Janine

AU - Lane, Patricia

AU - Munver, Ravi

AU - Esposito, Michael

AU - Sheuch, John

AU - Lanteri, Vincent

AU - Sawczuk, Ihor

N1 - Funding Information: Acknowledgements The authors gratefully acknowledge grant support awarded to the first author from The New Jersey Commission on Cancer Research (Grant no. 03-1139-CCR-EO) and the Institutional Minority Student Development Program (Grant no. 1 R25 GM 0826-02).

PY - 2009/5

Y1 - 2009/5

N2 - Goals of work: Treatments for early-stage prostate cancer (PCa) are highly effective; therefore, research studies that explore quality of life (QOL) issues associated with different treatments are important. The purposes of this study were to (a) examine differences among treatment groups of men treated with either radiation therapies or radical prostatectomy for PCa and (b) examine quality of life outcomes over time. Patients and methods: We report outcomes 6 and 12 months after 159 men began treatment for PCa with either one of two types of radiation treatment (intensity-modulated radiation therapy plus high dose rate or intensity-modulated radiation therapy plus seed implantation) or radical prostatectomy. Main results: Significant differences among groups are described. Significant predictors of QOL at 6 months included urinary, bowel, and sexual symptoms, anxiety, depression, problem-focused coping, and physiological self-efficacy. Significant predictors of QOL at 12 months were urinary and bowel symptoms, stress, depression, problem-focused coping, and physiological self-efficacy. Demographic variables, race, and living status were significant predictors of quality of life at 12 months. Conclusions: Physiological symptoms and psychological symptoms were both significant predictors of QOL. The psychological factors that predicted quality of life in this study have potential for intervention and point to the next stage of the research.

AB - Goals of work: Treatments for early-stage prostate cancer (PCa) are highly effective; therefore, research studies that explore quality of life (QOL) issues associated with different treatments are important. The purposes of this study were to (a) examine differences among treatment groups of men treated with either radiation therapies or radical prostatectomy for PCa and (b) examine quality of life outcomes over time. Patients and methods: We report outcomes 6 and 12 months after 159 men began treatment for PCa with either one of two types of radiation treatment (intensity-modulated radiation therapy plus high dose rate or intensity-modulated radiation therapy plus seed implantation) or radical prostatectomy. Main results: Significant differences among groups are described. Significant predictors of QOL at 6 months included urinary, bowel, and sexual symptoms, anxiety, depression, problem-focused coping, and physiological self-efficacy. Significant predictors of QOL at 12 months were urinary and bowel symptoms, stress, depression, problem-focused coping, and physiological self-efficacy. Demographic variables, race, and living status were significant predictors of quality of life at 12 months. Conclusions: Physiological symptoms and psychological symptoms were both significant predictors of QOL. The psychological factors that predicted quality of life in this study have potential for intervention and point to the next stage of the research.

KW - Oncology

KW - Prostate cancer

KW - Quality of life

KW - Radiation therapy

KW - Radical prostatectomy

UR - https://www.scopus.com/pages/publications/64449088232

U2 - 10.1007/s00520-008-0493-2

DO - 10.1007/s00520-008-0493-2

M3 - Article

C2 - 18719947

SN - 0941-4355

VL - 17

SP - 509

EP - 517

JO - Supportive Care in Cancer

JF - Supportive Care in Cancer

IS - 5

ER -