R-flurbiprofen, a novel nonsteroidal anti-inflammatory drug, decreases cell proliferation and induces apoptosis in pituitary adenoma cells in vitro

James K. Liu, Smruti K. Patel, David L. Gillespie, Kum Whang, William T. Couldwell

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

R-flurbiprofen, a nonsteroidal anti-inflammatory drug derivative, has been shown to inhibit colonic adenoma formation in mice. We investigated the effects of R-flurbiprofen on cell proliferation and apoptosis in pituitary adenoma cell lines. GH4C1 rat pituitary cell line cultures and low-passage human primary pituitary cell cultures were treated with varying concentrations of R-flurbiprofen (0.1-1.0 mM). R-flurbiprofen inhibited cell proliferation in a dose-dependent fashion. A terminal deoxynucleotidyl transferase dUTP nick end labeling assay and chromatin condensation/dead cell apoptosis assay demonstrated induction of apoptosis at higher concentrations of R-flurbiprofen. R-flurbiprofen decreases cell proliferation and induces apoptosis in pituitary adenoma cells in vitro. This may be a potential therapy in the management of pituitary adenoma.

Original languageEnglish (US)
Pages (from-to)561-569
Number of pages9
JournalJournal of neuro-oncology
Volume106
Issue number3
DOIs
StatePublished - Feb 2012

All Science Journal Classification (ASJC) codes

  • Clinical Neurology
  • Neurology
  • Oncology
  • Cancer Research

Keywords

  • Apoptosis
  • Cyclooxygenase-2
  • Nonsteroidal anti-inflammatory drug
  • Pituitary adenoma
  • R-flurbiprofen

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