Rapid label-free DNA quantification by multi-frequency impedance sensing on a chip

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

DNA quantification and characterization are of critical importance in disease diagnosis and clinical analysis, while label-free technology greatly simplifies the sensing protocol as it eliminates the extra step for attaching the indicator to DNA strands. In this work, we present a novel label-free DNA detection methodology based on electrical frequency-dependent impedance. The impedance of DNA strands conjunct with streptavidin-coated magnetic beads was measured at 8 different frequencies using an electrical impedance sensor integrated on a chip.

Original languageAmerican English
Title of host publicationMicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PublisherChemical and Biological Microsystems Society
Pages585-586
Number of pages2
ISBN (Electronic)9781733419017
StatePublished - 2020
Event24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2020 - Virtual, Online
Duration: Oct 4 2020Oct 9 2020

Publication series

NameMicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences

Conference

Conference24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2020
CityVirtual, Online
Period10/4/2010/9/20

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Bioengineering
  • General Chemistry
  • Control and Systems Engineering

Keywords

  • DNA quantification
  • Impedance flow cytometry
  • Label-free

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