Redistribution of blood flow after thermal injury and hemorrhagic shock

E. A. Carter, R. G. Tompkins, M. L. Yarmush, W. A. Walker, J. F. Burke

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Diminished mucosal mass and a diminished rate of DNA synthesis by the intestinal mucosa have been identified in the rat after thermal injury. Because these changes may be associated with ischemia, the distribution of intestinal blood flow was studied after a thermal injury and compared with the blood flow distribution after hemorrhagic shock. For the thermal injury, anesthetized animals received a standardized 20% body surface area, full-thickness injury and were given intraperitoneal saline resuscitation. By the use of 46Sc- or 141Ce-labeled microspheres, no changes in intestinal and hepatic blood flow occurred after thermal injury. In contrast, a marked redistribution of blood flow was identified after hemorrhagic shock in which a decrease in arterial blood flow was identified to the stomach and to the small and large intestine. Although clinical shock was not present, the cardiac output decreased to a comparable degree in the hemorrhagic shock and the thermal injury. These studies indicate that although physiological changes in intestinal mucosa can be demonstrated after burn injury, these changes are not due to decreases in mesenteric arterial blood flow.

Original languageEnglish (US)
Pages (from-to)1782-1788
Number of pages7
JournalJournal of applied physiology
Volume65
Issue number4
StatePublished - Jan 1 1988

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Hemorrhagic Shock
Hot Temperature
Wounds and Injuries
Intestinal Mucosa
Body Surface Area
Large Intestine
Microspheres
Resuscitation
Cardiac Output
Small Intestine
Shock
Stomach
Ischemia
Liver
DNA

All Science Journal Classification (ASJC) codes

  • Physiology (medical)
  • Physiology

Cite this

Carter, E. A., Tompkins, R. G., Yarmush, M. L., Walker, W. A., & Burke, J. F. (1988). Redistribution of blood flow after thermal injury and hemorrhagic shock. Journal of applied physiology, 65(4), 1782-1788.
Carter, E. A. ; Tompkins, R. G. ; Yarmush, M. L. ; Walker, W. A. ; Burke, J. F. / Redistribution of blood flow after thermal injury and hemorrhagic shock. In: Journal of applied physiology. 1988 ; Vol. 65, No. 4. pp. 1782-1788.
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Carter, EA, Tompkins, RG, Yarmush, ML, Walker, WA & Burke, JF 1988, 'Redistribution of blood flow after thermal injury and hemorrhagic shock', Journal of applied physiology, vol. 65, no. 4, pp. 1782-1788.

Redistribution of blood flow after thermal injury and hemorrhagic shock. / Carter, E. A.; Tompkins, R. G.; Yarmush, M. L.; Walker, W. A.; Burke, J. F.

In: Journal of applied physiology, Vol. 65, No. 4, 01.01.1988, p. 1782-1788.

Research output: Contribution to journalArticle

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Carter EA, Tompkins RG, Yarmush ML, Walker WA, Burke JF. Redistribution of blood flow after thermal injury and hemorrhagic shock. Journal of applied physiology. 1988 Jan 1;65(4):1782-1788.