Reduced plasticity of cortical whisker representation in adult tenascin-C-deficient mice after vibrissectomy

Anita Cybulska-Klosowicz, Renata Zakrzewska, Elzbieta Pyza, Malgorzata Kossut, Melitta Schachner

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

The effect of the extracellular matrix recognition molecule tenascin-C on cerebral plasticity induced by vibrissectomy was investigated with 2-deoxyglucose (2DG) brain mapping in tenascin-C-deficient mice. Unilateral vibrissectomy sparing row C of vibrissae was performed in young adult mice. Two months later, cortical representations of spared row C vibrissae and control row C on the other side of the snout were visualized by [14C]2DG autoradiography. In both wild-type and tenascin-C-deficient mice, cortical representation of the spared row was expanded in all layers of the barrel cortex. However, the effect was significantly more extensive in wild-type animals than in the mutant. Elimination of tenascin-C by genetic manipulation thus reduces the effect of vibrissectomy observed in the somatosensory cortex. No increase in number of fibres in the vibrissal nerve of spared vibrissae was seen, and occurrence of additional nerve to the spared follicle was very rare. Thus, in tenascin-C-deficient mice functional plasticity seems to be impaired within the CNS.

Original languageEnglish (US)
Pages (from-to)1538-1544
Number of pages7
JournalEuropean Journal of Neuroscience
Volume20
Issue number6
DOIs
StatePublished - Sep 2004
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)

Keywords

  • 2-deoxyglucose
  • Barrel cortex
  • Extracellular matrix
  • Plasticity
  • Vibrissectomy

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