Abstract
The distribution of blood flow was determined with radioactive microspheres following scald injury in guinea pigs. Burn was induced in halothane anesthetized guinea pigs by a 3-sec immersion to the xiphoid process in 100 degrees C water. Cardiac output and fractional blood flow measurements were made at preburn, 15-min postburn, and 75-min postburn. In the scalded animals cardiac output decreased 58% by 75 min postburn. Three different blood flow responses to burn were noted. Brain, heart, hepatic artery, and adrenals received an increased fraction to the cardiac output: the fractional distribution of the diaphragm, liver (portals), spleen, gastrointestinal tract, muscle (from burned portion of the body), and bone remained constant: while the pancreas, burned skin, nonburned skin, and adipose tissue received a reduced fraction of the cardiac output. Although some regions of the body (i.e. brain and heart) received a greater percentage of the total cardiac output after burn injury, the cardiac output decrease was sufficient to cause a depression in absolute blood flow to all but two sites (adrenals and hepatic artery).
| Original language | American English |
|---|---|
| Pages (from-to) | 317-326 |
| Number of pages | 10 |
| Journal | Circulatory Shock |
| Volume | 4 |
| Issue number | 4 |
| State | Published - 1977 |
| Externally published | Yes |
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine