Prostaglandin A1 (PGA1) administered intravenously in a dosage range of 0.01 to 1.0 μg per kilogram of body weight to unsedated, conscious dogs previously instrumented with Doppler ultrasonic or electromagnetic flow transducers caused dose-dependent decreases in arterial pressure and total systemic resistance and elevations in cardiac output and heart rate. PGA1 caused increases in blood flow and decreases in resistance in the left circumflex coronary, superior mesenteric, renal, and external iliac vascular beds. At the maximum dose of 1.0 μg per kilogram of body weight, when marked arterial hypotension had occurred, left circumflex coronary flow increased 74 per cent and mesenteric flow increased 76 per cent above control values while renal and iliac flows increased by only 14 per cent and 44 per cent, respectively. Thus PGA1, in doses tolerated by conscious dogs, increased cardiac output and blood flow to the left coronary, mesenteric, renal, and external iliac beds. At the dose of 1.0 μg per kilogram of body weight, which produced prominent arterial hypotension, the greatest relative increases in flow were observed in the coronary and superior mesenteric beds, while flow increased less in the iliac bed and least in the renal bed.
All Science Journal Classification (ASJC) codes
- Cardiology and Cardiovascular Medicine