Regulation of inflammation by airway smooth muscle

Research output: Contribution to journalReview article

23 Scopus citations

Abstract

Inflammatory mediators play a critical role in the pathogenesis of chronic airway diseases and facilitate the recruitment, activation, and trafficking of inflammatory cells in the airways. Compelling evidence now shows that airway smooth muscle expresses adhesion molecules and secretes inflammatory mediators. Airway myocytes also express a repertoire of immunomodulatory proteins such as Toll-like receptors, chemokines, and cytokines. The underlying mechanisms by which these molecules modulate airway inflammation and the physiological consequences of these molecules are now being elucidated, suggesting that airway smooth muscle plays an important role in orchestrating and perpetuating airway inflammation, remodeling, and fibrosis in chronic airway diseases.

Original languageEnglish (US)
Pages (from-to)262-268
Number of pages7
JournalCurrent Allergy and Asthma Reports
Volume8
Issue number3
DOIs
StatePublished - May 1 2008

All Science Journal Classification (ASJC) codes

  • Pulmonary and Respiratory Medicine
  • Immunology and Allergy
  • Immunology

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