In this paper, we reveal the formal algebraic structure underlying the in-trinsic reconstitution algorithm, introduced by Singer and Shkolnisky in , for determining three dimensional macromolecular structures from images obtained by an electron microscope. Inspecting this algebraic structure, we obtain a conceptual explanation for the admissibility (correctness) of the algorithm and a proof of its numerical stability. In addition, we explain how the various numerical observations reported in that work follow from basic representation theoretic principles.
ASJC Scopus subject areas
- Statistics and Probability
- Statistics, Probability and Uncertainty