Research fundamentals

Follow-up of subjects in clinical trials: Addressing subject attrition

Robert H. Woolard, Kathleen Carty, Philip Wirtz, Richard Longabaugh, Ted D. Nirenberg, P. Allison Minugh, Bruce Becker, Patrick Clifford

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Many published clinical trials have less than adequate follow-up. When conducting a clinical trial, researchers attempt to minimize data loss; however, some data may not be collected, particularly when subjects are lost to follow-up. Careful planning of research protocols, including comprehensive initial data collection, identification of locators, flexible scheduling, systematic subject tracking, monitoring subject loss, and systematically approaching problem cases can ensure high follow-up rates. This article presents a compendium of techniques and procedures that researchers can use to enhance follow-up and address attrition in their studies. Finally, this article outlines statistical techniques that can be used to address the effects of missing data, particularly when patients are lost to follow-up.

Original languageEnglish (US)
Pages (from-to)859-866
Number of pages8
JournalAcademic Emergency Medicine
Volume11
Issue number8
DOIs
StatePublished - Jan 1 2004

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Lost to Follow-Up
Research Personnel
Clinical Trials
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All Science Journal Classification (ASJC) codes

  • Emergency Medicine

Keywords

  • alcohol
  • attrition
  • follow-up
  • injury prevention
  • intoxication
  • missing data
  • research methodology

Cite this

Woolard, Robert H. ; Carty, Kathleen ; Wirtz, Philip ; Longabaugh, Richard ; Nirenberg, Ted D. ; Minugh, P. Allison ; Becker, Bruce ; Clifford, Patrick. / Research fundamentals : Follow-up of subjects in clinical trials: Addressing subject attrition. In: Academic Emergency Medicine. 2004 ; Vol. 11, No. 8. pp. 859-866.
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Woolard, RH, Carty, K, Wirtz, P, Longabaugh, R, Nirenberg, TD, Minugh, PA, Becker, B & Clifford, P 2004, 'Research fundamentals: Follow-up of subjects in clinical trials: Addressing subject attrition', Academic Emergency Medicine, vol. 11, no. 8, pp. 859-866. https://doi.org/10.1197/j.aem.2003.09.021

Research fundamentals : Follow-up of subjects in clinical trials: Addressing subject attrition. / Woolard, Robert H.; Carty, Kathleen; Wirtz, Philip; Longabaugh, Richard; Nirenberg, Ted D.; Minugh, P. Allison; Becker, Bruce; Clifford, Patrick.

In: Academic Emergency Medicine, Vol. 11, No. 8, 01.01.2004, p. 859-866.

Research output: Contribution to journalArticle

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