Abstract
The ability of reserpine and alpha-methyltyrosine (AMT) to alter the disruptive effects of phencyclidine was evaluated in rats responding for water delivery under a fixed-ratio schedule. It was observed that phencyclidine, when administered IP 15 min before the session, caused a dose-dependent decrease in responding (ED50 = 3.6 mg/kg). The maximum dose of reserpine which was without effect on responding when administered alone, significantly potentiated the disruptive effects of phencyclidine when it was administered as a 12 h pretreatment. The maximum dose of AMT which was without effect on responding when administered alone, did not alter the disruptive effects of phencyclidine when it was administered as a 2 h pretreatment. These observations are discussed in reference to the potentiation of phencyclidine-induced ataxia by reserpine.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 177-186 |
| Number of pages | 10 |
| Journal | Research Communications in Psychology, Psychiatry and Behavior |
| Volume | 12 |
| Issue number | 3 |
| State | Published - 1987 |
ASJC Scopus subject areas
- Psychiatry and Mental health