Reserpine potentiates the disruptive effects of phencyclidine on operant responding

G. C. Wagner, M. F. Jarvis, M. E. Herman

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

The ability of reserpine and alpha-methyltyrosine (AMT) to alter the disruptive effects of phencyclidine was evaluated in rats responding for water delivery under a fixed-ratio schedule. It was observed that phencyclidine, when administered IP 15 min before the session, caused a dose-dependent decrease in responding (ED50 = 3.6 mg/kg). The maximum dose of reserpine which was without effect on responding when administered alone, significantly potentiated the disruptive effects of phencyclidine when it was administered as a 12 h pretreatment. The maximum dose of AMT which was without effect on responding when administered alone, did not alter the disruptive effects of phencyclidine when it was administered as a 2 h pretreatment. These observations are discussed in reference to the potentiation of phencyclidine-induced ataxia by reserpine.

Original languageEnglish (US)
Pages (from-to)177-186
Number of pages10
JournalResearch Communications in Psychology, Psychiatry and Behavior
Volume12
Issue number3
StatePublished - 1987

ASJC Scopus subject areas

  • Psychiatry and Mental health

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