Responses to coronary artery occlusion in conscious dogs with selective cardiac denervation

Y. T. Shen, D. R. Knight, Stephen Vatner, W. C. Randall, J. X. Thomas

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

The extent to which cardiac denervation alters responses to myocardial ischemia remains controversial. This study compared responses to 24-h coronary artery occlusion (CAO) on measurements of wall thickness (ultrasonic crystals), regional myocardial blood flow (microspheres), and infarct size (triphenyltetrazolium chloride technique) in three groups of conscious dogs with 1) selective posterior left ventricular (LV) wall denervation, 2) selective ventricular denervation, or in 3) intact dogs. After CAO, hemodynamic changes were not different among the three groups. Wall thickening in the ischemic zone became akinetic or paradoxical early after CAO and did not recover in any group over the 24-h monitoring period. Blood flow in the area at risk fell similarly in all groups. Infarct size, as a percentage of the area at risk, was 45 ± 7% in intact, 48 ± 6% in posterior LV wall-denervated, and 48 ± 8% in ventricular-denervated group. There was, however, a lower (P < 0.05) frequency of arrhythmic beats per minute after 3 h of CAO in the ventricular-denervated group (3.2 ± 1.4) compared with the intact (11.3 ± 4.1) or posterior wall-denervated (12.6 ± 3.2) group. An additional group of ventricular-denervated dogs was studied to determine th effects of sequential, brief 2-min CAO at 2, 4, and 8 wk after denervation. Responses of regional wall thickening to CAO were not affected significantly even after 8 wk following ventricular denervation. Thus, in conscious dogs, neither selective ventricular denervation nor selective denervation of the posterior LV wall improved collateral blood flow, affected regional function favorably, or reduced infarct size after CAO.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume255
Issue number3
StatePublished - Jan 1 1988

Fingerprint

Coronary Occlusion
Denervation
Coronary Vessels
Dogs
Regional Blood Flow
Microspheres
Ultrasonics
Myocardial Ischemia
Hemodynamics

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)
  • Physiology

Cite this

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title = "Responses to coronary artery occlusion in conscious dogs with selective cardiac denervation",
abstract = "The extent to which cardiac denervation alters responses to myocardial ischemia remains controversial. This study compared responses to 24-h coronary artery occlusion (CAO) on measurements of wall thickness (ultrasonic crystals), regional myocardial blood flow (microspheres), and infarct size (triphenyltetrazolium chloride technique) in three groups of conscious dogs with 1) selective posterior left ventricular (LV) wall denervation, 2) selective ventricular denervation, or in 3) intact dogs. After CAO, hemodynamic changes were not different among the three groups. Wall thickening in the ischemic zone became akinetic or paradoxical early after CAO and did not recover in any group over the 24-h monitoring period. Blood flow in the area at risk fell similarly in all groups. Infarct size, as a percentage of the area at risk, was 45 ± 7{\%} in intact, 48 ± 6{\%} in posterior LV wall-denervated, and 48 ± 8{\%} in ventricular-denervated group. There was, however, a lower (P < 0.05) frequency of arrhythmic beats per minute after 3 h of CAO in the ventricular-denervated group (3.2 ± 1.4) compared with the intact (11.3 ± 4.1) or posterior wall-denervated (12.6 ± 3.2) group. An additional group of ventricular-denervated dogs was studied to determine th effects of sequential, brief 2-min CAO at 2, 4, and 8 wk after denervation. Responses of regional wall thickening to CAO were not affected significantly even after 8 wk following ventricular denervation. Thus, in conscious dogs, neither selective ventricular denervation nor selective denervation of the posterior LV wall improved collateral blood flow, affected regional function favorably, or reduced infarct size after CAO.",
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Responses to coronary artery occlusion in conscious dogs with selective cardiac denervation. / Shen, Y. T.; Knight, D. R.; Vatner, Stephen; Randall, W. C.; Thomas, J. X.

In: American Journal of Physiology - Heart and Circulatory Physiology, Vol. 255, No. 3, 01.01.1988.

Research output: Contribution to journalArticle

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T1 - Responses to coronary artery occlusion in conscious dogs with selective cardiac denervation

AU - Shen, Y. T.

AU - Knight, D. R.

AU - Vatner, Stephen

AU - Randall, W. C.

AU - Thomas, J. X.

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N2 - The extent to which cardiac denervation alters responses to myocardial ischemia remains controversial. This study compared responses to 24-h coronary artery occlusion (CAO) on measurements of wall thickness (ultrasonic crystals), regional myocardial blood flow (microspheres), and infarct size (triphenyltetrazolium chloride technique) in three groups of conscious dogs with 1) selective posterior left ventricular (LV) wall denervation, 2) selective ventricular denervation, or in 3) intact dogs. After CAO, hemodynamic changes were not different among the three groups. Wall thickening in the ischemic zone became akinetic or paradoxical early after CAO and did not recover in any group over the 24-h monitoring period. Blood flow in the area at risk fell similarly in all groups. Infarct size, as a percentage of the area at risk, was 45 ± 7% in intact, 48 ± 6% in posterior LV wall-denervated, and 48 ± 8% in ventricular-denervated group. There was, however, a lower (P < 0.05) frequency of arrhythmic beats per minute after 3 h of CAO in the ventricular-denervated group (3.2 ± 1.4) compared with the intact (11.3 ± 4.1) or posterior wall-denervated (12.6 ± 3.2) group. An additional group of ventricular-denervated dogs was studied to determine th effects of sequential, brief 2-min CAO at 2, 4, and 8 wk after denervation. Responses of regional wall thickening to CAO were not affected significantly even after 8 wk following ventricular denervation. Thus, in conscious dogs, neither selective ventricular denervation nor selective denervation of the posterior LV wall improved collateral blood flow, affected regional function favorably, or reduced infarct size after CAO.

AB - The extent to which cardiac denervation alters responses to myocardial ischemia remains controversial. This study compared responses to 24-h coronary artery occlusion (CAO) on measurements of wall thickness (ultrasonic crystals), regional myocardial blood flow (microspheres), and infarct size (triphenyltetrazolium chloride technique) in three groups of conscious dogs with 1) selective posterior left ventricular (LV) wall denervation, 2) selective ventricular denervation, or in 3) intact dogs. After CAO, hemodynamic changes were not different among the three groups. Wall thickening in the ischemic zone became akinetic or paradoxical early after CAO and did not recover in any group over the 24-h monitoring period. Blood flow in the area at risk fell similarly in all groups. Infarct size, as a percentage of the area at risk, was 45 ± 7% in intact, 48 ± 6% in posterior LV wall-denervated, and 48 ± 8% in ventricular-denervated group. There was, however, a lower (P < 0.05) frequency of arrhythmic beats per minute after 3 h of CAO in the ventricular-denervated group (3.2 ± 1.4) compared with the intact (11.3 ± 4.1) or posterior wall-denervated (12.6 ± 3.2) group. An additional group of ventricular-denervated dogs was studied to determine th effects of sequential, brief 2-min CAO at 2, 4, and 8 wk after denervation. Responses of regional wall thickening to CAO were not affected significantly even after 8 wk following ventricular denervation. Thus, in conscious dogs, neither selective ventricular denervation nor selective denervation of the posterior LV wall improved collateral blood flow, affected regional function favorably, or reduced infarct size after CAO.

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