Abstract
The pedunculopontine nucleus (PPN) has long been considered an interface between the basal ganglia and motor systems, and its ability to regulate arousal states puts the PPN in a key position to modulate behavior. Despite the large amount of data obtained over recent decades, a unified theory of its function is still incomplete. By putting together classical concepts and new evidence that dissects the influence of its different neuronal subtypes on their various targets, we propose that the PPN and, in particular, cholinergic neurons have a central role in updating the behavioral state as a result of changes in environmental contingencies. Such a function is accomplished by a combined mechanism that simultaneously restrains ongoing obsolete actions while it facilitates new contextual associations.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 7-18 |
| Number of pages | 12 |
| Journal | Neuron |
| Volume | 94 |
| Issue number | 1 |
| DOIs | |
| State | Published - Apr 5 2017 |
Fingerprint
All Science Journal Classification (ASJC) codes
- Neuroscience(all)
Keywords
- arousal
- basal ganglia
- brainstem
- cholinergic
- laterodorsal tegmental
- locomotion
- reward
- reward prediction error
- saliency
- striatum
Cite this
}
Rethinking the Pedunculopontine Nucleus : From Cellular Organization to Function. / Mena Segovia, Juan; Bolam, J. Paul.
In: Neuron, Vol. 94, No. 1, 05.04.2017, p. 7-18.Research output: Contribution to journal › Review article
TY - JOUR
T1 - Rethinking the Pedunculopontine Nucleus
T2 - From Cellular Organization to Function
AU - Mena Segovia, Juan
AU - Bolam, J. Paul
PY - 2017/4/5
Y1 - 2017/4/5
N2 - The pedunculopontine nucleus (PPN) has long been considered an interface between the basal ganglia and motor systems, and its ability to regulate arousal states puts the PPN in a key position to modulate behavior. Despite the large amount of data obtained over recent decades, a unified theory of its function is still incomplete. By putting together classical concepts and new evidence that dissects the influence of its different neuronal subtypes on their various targets, we propose that the PPN and, in particular, cholinergic neurons have a central role in updating the behavioral state as a result of changes in environmental contingencies. Such a function is accomplished by a combined mechanism that simultaneously restrains ongoing obsolete actions while it facilitates new contextual associations.
AB - The pedunculopontine nucleus (PPN) has long been considered an interface between the basal ganglia and motor systems, and its ability to regulate arousal states puts the PPN in a key position to modulate behavior. Despite the large amount of data obtained over recent decades, a unified theory of its function is still incomplete. By putting together classical concepts and new evidence that dissects the influence of its different neuronal subtypes on their various targets, we propose that the PPN and, in particular, cholinergic neurons have a central role in updating the behavioral state as a result of changes in environmental contingencies. Such a function is accomplished by a combined mechanism that simultaneously restrains ongoing obsolete actions while it facilitates new contextual associations.
KW - arousal
KW - basal ganglia
KW - brainstem
KW - cholinergic
KW - laterodorsal tegmental
KW - locomotion
KW - reward
KW - reward prediction error
KW - saliency
KW - striatum
UR - http://www.scopus.com/inward/record.url?scp=85017036119&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85017036119&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.neuron.2017.02.027
DO - https://doi.org/10.1016/j.neuron.2017.02.027
M3 - Review article
C2 - 28384477
VL - 94
SP - 7
EP - 18
JO - Neuron
JF - Neuron
SN - 0896-6273
IS - 1
ER -