Rifaximin is a gut-specific human pregnane X receptor activator

Keyphrases

• Rifaximin 100%
• Pregnane X Receptor 100%
• Chronic Gastrointestinal Diseases 25%
• Receptor Targets 16%
• Ligand-receptor Binding 16%
• Rifampicin 16%
• Peroxisome Proliferator-activated Receptor 16%
• Nuclear Receptor 16%
• Xenobiotics 16%
• Cell-based 8%
• Wild Mice 8%
• Null Mice 8%
• Human Studies 8%
• Receptor Activation 8%
• Intestine 8%
• Pharmacokinetics 8%
• In Vivo Data 8%
• Farnesoid X Receptor 8%
• Reporter Gene Assay 8%
• Humanized 8%
• Rifamycin 8%
• Constitutive Androstane Receptor 8%
• Intestinal Tract 8%
• Multiple Chronic Conditions 8%
• Highly Concentrated 8%
• Tmax 8%
• Midazolam 8%
• Cytochrome P450 3A (CYP3A) 8%
• Cmax 8%
• Travelers' Diarrhea 8%
• Endobiotics 8%
• Detoxication 8%
• 1-hydroxymidazolam 8%

Pharmacology, Toxicology and Pharmaceutical Science

• Rifaximin 100%
• Pregnane X Receptor 100%
• Gastrointestinal Disease 25%
• Rifampicin 16%
• Cell Nucleus Receptor 16%
• Peroxisome Proliferator Activated Receptor 16%
• Wild Type Mouse 8%
• Detoxication 8%
• Human Study 8%
• Farnesoid X Receptor 8%
• Rifamycin 8%
• Constitutive Androstane Receptor 8%
• Midazolam 8%
• CYP3A 8%
• Traveller Diarrhea 8%
• Pregnane X Receptor Knockout Mouse 8%
• Pharmacokinetics 8%