Risk to Nonparticipants in HIV Remission Studies with Treatment Interruption: A Symposium

Nir Eyal, Steven G. Deeks

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Ethical guidelines and recommendations for human subjects research typically focus on protecting the individuals who directly participate in that research. However, additional people, including sex partners of research participants, can also face harms and burdens from medical studies. In human immunodeficiency virus (HIV) cure-related research, a persistent ethical and practical challenge surrounds the use of analytical antiretroviral treatment interruptions. The challenge is usually discussed in relation to risks to study participants, but serious dangers accrue to nonparticipants, including sex partners of study participants. This multidisciplinary supplement relays the risks for nonparticipating sex partners in HIV cure-related studies and addresses the ethical dilemmas raised by these studies, with recommendations for researchers, advocates, sponsors, and oversight bodies.

Original languageEnglish (US)
Pages (from-to)S1-S4
JournalJournal of Infectious Diseases
Volume220
DOIs
StatePublished - Jul 2 2019

All Science Journal Classification (ASJC) codes

  • Infectious Diseases
  • Immunology and Allergy

Keywords

  • HIV
  • HIV cure-related studies
  • analytic treatment interruption
  • immunotherapy
  • pre-exposure prophylaxis
  • research ethics

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