Abstract
Nuclear receptors (NRs) are ligand-activated transcription factors that are important to life by regulating a wide varietyof physiological and pathological functions. There are three classes of NRs defined by ligands and heterodimer parstners. The Class IINRs are involved in a broad range of pathophysiological functions in the liver, including cholesterol and bile acid homeostasis; lipidand glucose metabolism; inflammation; liver regeneration and hepatocellular carcinogenesis. Due to highly complicated molecularmechanisms in the development and progression of hepatocellular carcinoma (HCC), HCC is still one of the most common malignanciesin the world. Given the pivotal functions of the Class II NRs in the liver, the roles of these NRs in hepatocellular carcinogenesis areemerging. This review summarizes the roles of Class II NRs in liver carcinogenesis and their potential application in the prevention andtreatment of HCC.
Original language | American English |
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Pages (from-to) | 529-542 |
Number of pages | 14 |
Journal | Anti-Cancer Agents in Medicinal Chemistry |
Volume | 11 |
Issue number | 6 |
DOIs | |
State | Published - Jul 2011 |
Externally published | Yes |
ASJC Scopus subject areas
- Molecular Medicine
- Pharmacology
- Cancer Research
Keywords
- Class II nuclear receptors
- Constitutive androstane receptor
- Farnesoid X receptor
- Hepatocellular carcinoma
- Liver X receptors
- Peroxisome proliferator-activated receptors
- Pregnane X receptor
- Retinoic acid receptors