Role of dorsal root ganglion K2p1.1 in peripheral nerve injury-induced neuropathic pain

Qingxiang Mao, Jingjing Yuan, Ming Xiong, Shaogen Wu, Liyong Chen, Alex Bekker, Yuan Xiang Tao, Tiande Yang

Research output: Contribution to journalArticle

3 Scopus citations


Peripheral nerve injury-caused hyperexcitability and abnormal ectopic discharges in the primary sensory neurons of dorsal root ganglion (DRG) play a key role in neuropathic pain development and maintenance. The two-pore domain background potassium (K2P) channels have been identified as key determinants of the resting membrane potential and neuronal excitability. However, whether K2P channels contribute to neuropathic pain is still elusive. We reported here that K2P1.1, the first identified mammalian K2P channel, was highly expressed in mouse DRG and distributed in small-, medium-, and large-sized DRG neurons. Unilateral lumbar (L) 4 spinal nerve ligation led to a significant and time-dependent reduction of K2P1.1 mRNA and protein in the ipsilateral L4 DRG, but not in the contralateral L4 or ipsilateral L3 DRG. Rescuing this reduction through microinjection of adeno-associated virus-DJ expressing full-length K2P1.1 mRNA into the ipsilateral L4 DRG blocked spinal nerve ligation-induced mechanical, thermal, and cold pain hypersensitivities during the development and maintenance periods. This DRG viral microinjection did not affect acute pain and locomotor function. Our findings suggest that K2P1.1 participates in neuropathic pain development and maintenance and may be a potential target in the management of this disorder.

Original languageEnglish (US)
JournalMolecular Pain
StatePublished - 2017

All Science Journal Classification (ASJC) codes

  • Anesthesiology and Pain Medicine
  • Cellular and Molecular Neuroscience
  • Molecular Medicine


  • Dorsal root ganglion
  • K1.1
  • Neuropathic pain
  • Potassium channels
  • Twik1

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