@inproceedings{efd7f9310b194b00930c1f880f2ab180,
title = "Role of vector in the dynamics of antisense activity",
abstract = "The objective of this work is to investigate the role of the vector in the dynamics of antisense effects. Polymer/DNA complexes between cationic, branched polymer, polyethylenimine (PEI) at a range of molecular weights and oligonucleotides (ODNs), with varying backbone chemistries, were studied using a variety of physico-chemical and cellular assays. The extent and time scale of antisense effects were found to depend strongly on both the polymer molecular weight as well as the ODN chemistry. The optimum molecular weight of PEI for maximum ODN delivery depends strongly on the ODN chemistry.",
keywords = "Antisense, Cellular uptake, GFP down-regulation, Polyethylenimine",
author = "Sumati Sundaram and Lee, {Li Kim} and Roth, {Charles M.}",
year = "2006",
language = "English (US)",
isbn = "0780395638",
series = "Bioengineering, Proceedings of the Northeast Conference",
pages = "181--182",
booktitle = "Proceedings of the IEEE 32nd Annual Northeast Bioengineering Conference, 2006",
note = "IEEE 32nd Annual Northeast Bioengineering Conference, 2006 ; Conference date: 01-04-2006 Through 02-04-2006",
}