Ruthenium(II)-Catalyzed Direct C-H Arylation of Indoles with Arylsilanes in Water

Pradeep Nareddy, Frank Jordan, Michal Szostak

Research output: Contribution to journalArticle

43 Scopus citations

Abstract

The ruthenium(II)-catalyzed, heteroatom-directed C-H arylation of indoles with arylsilanes in water has been developed. The method represents the first example of a ruthenium(II)-catalyzed oxidative C-H arylation in water/aqueous media as a sustainable solvent for C-H functionalization. The reaction enables the synthesis of a wide range of indoles with exquisite selectivity for arylation at the C-2 position. Preliminary mechanistic studies indicate reversibility of the C-H ruthenation step under the developed reaction conditions.

Original languageEnglish (US)
Pages (from-to)341-344
Number of pages4
JournalOrganic letters
Volume20
Issue number2
DOIs
StatePublished - Jan 19 2018

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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