Safety of selegiline with cold medications

Jeena E. Jacob; Mary L. Wagner; Jacob I. Sage; Christina Dalmady-Israel; Bruno Edouard

doi:10.1345/aph.1C175

Safety of selegiline with cold medications

Jeena E. Jacob, Mary L. Wagner, Jacob I. Sage, Christina Dalmady-Israel, Bruno Edouard

Rutgers, The State University

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

OBJECTIVE: To evaluate the safety of the coadministration of selegiline with cold medications. DATA SOURCES: Clinical literature accessed through MEDLINE(1965-September 2002), IPA database, and Drug-Reax System. The following search terms were used: selegiline, pseudoephedrine, dextromethorphan, MAOI, and drug interactions. Somerset Pharmaceuticals, the marketers of Eldepryl (selegiline HCI), were also contacted. DATA SYNTHESIS: Despite a warning against its concomitant use with pseudoephedrine and dextromethorphan, interactions with selegiline have not been reported. However, there have been reports of patients experiencing adverse events with related agents. CONCLUSIONS: Patients taking selegiline should try to avoid pseudoephedrine and dextromethorphan or use drugs without interaction potential. If selegiline is used with these medications, watch for adverse events or replace selegiline with another drug.

Original language	American English
Pages (from-to)	438-441
Number of pages	4
Journal	Annals of Pharmacotherapy
Volume	37
Issue number	3
DOIs	https://doi.org/10.1345/aph.1C175
State	Published - Mar 1 2003

ASJC Scopus subject areas

Pharmacology (medical)

Keywords

Dextromethorphan
Parkinson disease
Pseudoephedrine
Selegiline

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10.1345/aph.1C175

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abstract = "OBJECTIVE: To evaluate the safety of the coadministration of selegiline with cold medications. DATA SOURCES: Clinical literature accessed through MEDLINE(1965-September 2002), IPA database, and Drug-Reax System. The following search terms were used: selegiline, pseudoephedrine, dextromethorphan, MAOI, and drug interactions. Somerset Pharmaceuticals, the marketers of Eldepryl (selegiline HCI), were also contacted. DATA SYNTHESIS: Despite a warning against its concomitant use with pseudoephedrine and dextromethorphan, interactions with selegiline have not been reported. However, there have been reports of patients experiencing adverse events with related agents. CONCLUSIONS: Patients taking selegiline should try to avoid pseudoephedrine and dextromethorphan or use drugs without interaction potential. If selegiline is used with these medications, watch for adverse events or replace selegiline with another drug.",

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AU - Wagner, Mary L.

AU - Sage, Jacob I.

AU - Dalmady-Israel, Christina

AU - Edouard, Bruno

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N2 - OBJECTIVE: To evaluate the safety of the coadministration of selegiline with cold medications. DATA SOURCES: Clinical literature accessed through MEDLINE(1965-September 2002), IPA database, and Drug-Reax System. The following search terms were used: selegiline, pseudoephedrine, dextromethorphan, MAOI, and drug interactions. Somerset Pharmaceuticals, the marketers of Eldepryl (selegiline HCI), were also contacted. DATA SYNTHESIS: Despite a warning against its concomitant use with pseudoephedrine and dextromethorphan, interactions with selegiline have not been reported. However, there have been reports of patients experiencing adverse events with related agents. CONCLUSIONS: Patients taking selegiline should try to avoid pseudoephedrine and dextromethorphan or use drugs without interaction potential. If selegiline is used with these medications, watch for adverse events or replace selegiline with another drug.

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Safety of selegiline with cold medications

Abstract

ASJC Scopus subject areas

Keywords

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