Salvage treatment for local recurrence after breast-conserving surgery and radiation as initial treatment for mammographically detected ductal carcinoma in situ of the breast

Lawrence J. Solin, Alain Fourquet, Frank A. Vicini, Bruce Haffty, Marie Taylor, Beryl McCormick, Marsha McNeese

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

BACKGROUND. The purpose of the current study is to evaluate the outcome of salvage treatment for local recurrence after breast-conserving surgery and radiation as initial treatment for mammographically detected ductal carcinoma in situ (DCIS; intraductal carcinoma) of the breast. METHODS. An analysis was performed of 42 patients with local only first failure (n = 41) or local-regional only first failure (n = 1) after breast-conserving surgery and radiation treatment had been given for DCIS of the breast. Surgical treatment at the time of local recurrence included mastectomy (n = 37; 88%) or excision (n = 5; 12%). Adjuvant systemic therapy at the time of local recurrence was chemotherapy (n = 3; 7%), tamoxifen (n = 8; 19%), both (n = 1; 2%), none (n = 29; 69%), or unknown (n = 1; 2%). The median interval from the time of initial treatment to local recurrence was 4.8 years (range = 1.0-15.2 yrs). The median follow-up after salvage treatment was 4.5 years (range = 0.2-12.8 yrs). RESULTS. At the time of the local recurrence, 22 patients (52%) had invasive ductal carcinoma, 18 patients (43%) had DCIS, 1 patient (2%) had invasive lobular carcinoma, and 1 patient (2%) had angiosarcoma. After salvage treatment, the rate of overall survival and the rate of cause specific survival for all 42 patients were 92% at both 5- and 8-years after treatment. The rate of freedom from distant metastases was 89% at 5 and 8 years. Favorable prognostic factors after salvage treatment were DCIS as the histology of the local recurrence and mammography only as the method of detection of the local recurrence. CONCLUSIONS. The results of salvage treatment in the current study demonstrated that local recurrences were salvaged with high rates of survival and freedom from distant metastases. These results support the use of breast-conserving surgery and radiation for initial management of DCIS of the breast.

Original languageEnglish (US)
Pages (from-to)1090-1097
Number of pages8
JournalCancer
Volume91
Issue number6
DOIs
StatePublished - Mar 15 2001

Fingerprint

Salvage Therapy
Carcinoma, Intraductal, Noninfiltrating
Segmental Mastectomy
Breast
Radiation
Recurrence
Therapeutics
Survival Rate
Neoplasm Metastasis
Lobular Carcinoma
Ductal Carcinoma
Hemangiosarcoma
Mastectomy
Mammography
Tamoxifen
Histology
Drug Therapy
Survival

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Solin, Lawrence J. ; Fourquet, Alain ; Vicini, Frank A. ; Haffty, Bruce ; Taylor, Marie ; McCormick, Beryl ; McNeese, Marsha. / Salvage treatment for local recurrence after breast-conserving surgery and radiation as initial treatment for mammographically detected ductal carcinoma in situ of the breast. In: Cancer. 2001 ; Vol. 91, No. 6. pp. 1090-1097.
@article{06a4a8ba10cc4e67a136b39b74d2bfdb,
title = "Salvage treatment for local recurrence after breast-conserving surgery and radiation as initial treatment for mammographically detected ductal carcinoma in situ of the breast",
abstract = "BACKGROUND. The purpose of the current study is to evaluate the outcome of salvage treatment for local recurrence after breast-conserving surgery and radiation as initial treatment for mammographically detected ductal carcinoma in situ (DCIS; intraductal carcinoma) of the breast. METHODS. An analysis was performed of 42 patients with local only first failure (n = 41) or local-regional only first failure (n = 1) after breast-conserving surgery and radiation treatment had been given for DCIS of the breast. Surgical treatment at the time of local recurrence included mastectomy (n = 37; 88{\%}) or excision (n = 5; 12{\%}). Adjuvant systemic therapy at the time of local recurrence was chemotherapy (n = 3; 7{\%}), tamoxifen (n = 8; 19{\%}), both (n = 1; 2{\%}), none (n = 29; 69{\%}), or unknown (n = 1; 2{\%}). The median interval from the time of initial treatment to local recurrence was 4.8 years (range = 1.0-15.2 yrs). The median follow-up after salvage treatment was 4.5 years (range = 0.2-12.8 yrs). RESULTS. At the time of the local recurrence, 22 patients (52{\%}) had invasive ductal carcinoma, 18 patients (43{\%}) had DCIS, 1 patient (2{\%}) had invasive lobular carcinoma, and 1 patient (2{\%}) had angiosarcoma. After salvage treatment, the rate of overall survival and the rate of cause specific survival for all 42 patients were 92{\%} at both 5- and 8-years after treatment. The rate of freedom from distant metastases was 89{\%} at 5 and 8 years. Favorable prognostic factors after salvage treatment were DCIS as the histology of the local recurrence and mammography only as the method of detection of the local recurrence. CONCLUSIONS. The results of salvage treatment in the current study demonstrated that local recurrences were salvaged with high rates of survival and freedom from distant metastases. These results support the use of breast-conserving surgery and radiation for initial management of DCIS of the breast.",
author = "Solin, {Lawrence J.} and Alain Fourquet and Vicini, {Frank A.} and Bruce Haffty and Marie Taylor and Beryl McCormick and Marsha McNeese",
year = "2001",
month = "3",
day = "15",
doi = "https://doi.org/10.1002/1097-0142(20010315)91:6<1090::AID-CNCR1104>3.0.CO;2-D",
language = "English (US)",
volume = "91",
pages = "1090--1097",
journal = "Cancer",
issn = "0008-543X",
publisher = "John Wiley and Sons Inc.",
number = "6",

}

Salvage treatment for local recurrence after breast-conserving surgery and radiation as initial treatment for mammographically detected ductal carcinoma in situ of the breast. / Solin, Lawrence J.; Fourquet, Alain; Vicini, Frank A.; Haffty, Bruce; Taylor, Marie; McCormick, Beryl; McNeese, Marsha.

In: Cancer, Vol. 91, No. 6, 15.03.2001, p. 1090-1097.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Salvage treatment for local recurrence after breast-conserving surgery and radiation as initial treatment for mammographically detected ductal carcinoma in situ of the breast

AU - Solin, Lawrence J.

AU - Fourquet, Alain

AU - Vicini, Frank A.

AU - Haffty, Bruce

AU - Taylor, Marie

AU - McCormick, Beryl

AU - McNeese, Marsha

PY - 2001/3/15

Y1 - 2001/3/15

N2 - BACKGROUND. The purpose of the current study is to evaluate the outcome of salvage treatment for local recurrence after breast-conserving surgery and radiation as initial treatment for mammographically detected ductal carcinoma in situ (DCIS; intraductal carcinoma) of the breast. METHODS. An analysis was performed of 42 patients with local only first failure (n = 41) or local-regional only first failure (n = 1) after breast-conserving surgery and radiation treatment had been given for DCIS of the breast. Surgical treatment at the time of local recurrence included mastectomy (n = 37; 88%) or excision (n = 5; 12%). Adjuvant systemic therapy at the time of local recurrence was chemotherapy (n = 3; 7%), tamoxifen (n = 8; 19%), both (n = 1; 2%), none (n = 29; 69%), or unknown (n = 1; 2%). The median interval from the time of initial treatment to local recurrence was 4.8 years (range = 1.0-15.2 yrs). The median follow-up after salvage treatment was 4.5 years (range = 0.2-12.8 yrs). RESULTS. At the time of the local recurrence, 22 patients (52%) had invasive ductal carcinoma, 18 patients (43%) had DCIS, 1 patient (2%) had invasive lobular carcinoma, and 1 patient (2%) had angiosarcoma. After salvage treatment, the rate of overall survival and the rate of cause specific survival for all 42 patients were 92% at both 5- and 8-years after treatment. The rate of freedom from distant metastases was 89% at 5 and 8 years. Favorable prognostic factors after salvage treatment were DCIS as the histology of the local recurrence and mammography only as the method of detection of the local recurrence. CONCLUSIONS. The results of salvage treatment in the current study demonstrated that local recurrences were salvaged with high rates of survival and freedom from distant metastases. These results support the use of breast-conserving surgery and radiation for initial management of DCIS of the breast.

AB - BACKGROUND. The purpose of the current study is to evaluate the outcome of salvage treatment for local recurrence after breast-conserving surgery and radiation as initial treatment for mammographically detected ductal carcinoma in situ (DCIS; intraductal carcinoma) of the breast. METHODS. An analysis was performed of 42 patients with local only first failure (n = 41) or local-regional only first failure (n = 1) after breast-conserving surgery and radiation treatment had been given for DCIS of the breast. Surgical treatment at the time of local recurrence included mastectomy (n = 37; 88%) or excision (n = 5; 12%). Adjuvant systemic therapy at the time of local recurrence was chemotherapy (n = 3; 7%), tamoxifen (n = 8; 19%), both (n = 1; 2%), none (n = 29; 69%), or unknown (n = 1; 2%). The median interval from the time of initial treatment to local recurrence was 4.8 years (range = 1.0-15.2 yrs). The median follow-up after salvage treatment was 4.5 years (range = 0.2-12.8 yrs). RESULTS. At the time of the local recurrence, 22 patients (52%) had invasive ductal carcinoma, 18 patients (43%) had DCIS, 1 patient (2%) had invasive lobular carcinoma, and 1 patient (2%) had angiosarcoma. After salvage treatment, the rate of overall survival and the rate of cause specific survival for all 42 patients were 92% at both 5- and 8-years after treatment. The rate of freedom from distant metastases was 89% at 5 and 8 years. Favorable prognostic factors after salvage treatment were DCIS as the histology of the local recurrence and mammography only as the method of detection of the local recurrence. CONCLUSIONS. The results of salvage treatment in the current study demonstrated that local recurrences were salvaged with high rates of survival and freedom from distant metastases. These results support the use of breast-conserving surgery and radiation for initial management of DCIS of the breast.

UR - http://www.scopus.com/inward/record.url?scp=0035868556&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035868556&partnerID=8YFLogxK

U2 - https://doi.org/10.1002/1097-0142(20010315)91:6<1090::AID-CNCR1104>3.0.CO;2-D

DO - https://doi.org/10.1002/1097-0142(20010315)91:6<1090::AID-CNCR1104>3.0.CO;2-D

M3 - Article

C2 - 11267953

VL - 91

SP - 1090

EP - 1097

JO - Cancer

JF - Cancer

SN - 0008-543X

IS - 6

ER -