Sarcoid and cytotoxic lung antibodies

Norman Ende, Joseph N. Grizzanti, Ernest V. Orsi, Kenneth P. Lubansky, Robert C. Amoruso, Lee B. Reichman, Judy T. Zelikoff

Research output: Contribution to journalArticlepeer-review

Abstract

Fifteen cases of Sarcoidosis were investigated for the presence of complement dependent cytotoxicity against human lung cells grown in tissue culture. Significant levels were found in eleven cases. Absorption studies revealed that these antibodies associated with sarcoidosis could be absorbed by human lung fibroblasts but not by fibroblasts derived from human foreskin or kidney. Although we found a similar antibody frequently associated with extrinsic asthma we have only rarely found these antibodies in cases of tubercolosis, carcinoma of the lung, emphysema and intrinsic asthma.

Original languageEnglish (US)
Pages (from-to)2435-2440
Number of pages6
JournalLife Sciences
Volume39
Issue number25
DOIs
StatePublished - Dec 22 1986

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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