Scale-up strategy for continuous powder blending process

Yijie Gao; Fernando J. Muzzio

doi:https://doi.org/10.1016/j.powtec.2012.09.036

Scale-up strategy for continuous powder blending process

Yijie Gao, Fernando J. Muzzio

School of Engineering, Chemical & Biochemical Engineering

Rutgers, The State University

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Continuous powder mixing has attracted a lot of interest within the pharmaceutical industry. Much work has been done recently that targets the characterization of continuous powder mixing. In this paper, a quantitative scaling up strategy is introduced that allows the transition from lab to industrial scale. The proposed methodology is based on the variance spectrum analysis, and the residence time distribution, which are key indexes in capturing scale-up of the batch-like mixing, and scale-up of the axial mixing and motion, respectively. Our simulation results are used as preliminary guidance for scaling up different powder mixing cases.

Original language	English (US)
Pages (from-to)	55-69
Number of pages	15
Journal	Powder Technology
Volume	235
DOIs	https://doi.org/10.1016/j.powtec.2012.09.036
State	Published - Feb 2013

ASJC Scopus subject areas

Chemical Engineering(all)

Keywords

DEM
Periodic section modeling
Powder blending
RTD
Sample size
Scale-up

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title = "Scale-up strategy for continuous powder blending process",

abstract = "Continuous powder mixing has attracted a lot of interest within the pharmaceutical industry. Much work has been done recently that targets the characterization of continuous powder mixing. In this paper, a quantitative scaling up strategy is introduced that allows the transition from lab to industrial scale. The proposed methodology is based on the variance spectrum analysis, and the residence time distribution, which are key indexes in capturing scale-up of the batch-like mixing, and scale-up of the axial mixing and motion, respectively. Our simulation results are used as preliminary guidance for scaling up different powder mixing cases.",

keywords = "DEM, Periodic section modeling, Powder blending, RTD, Sample size, Scale-up",

author = "Yijie Gao and Muzzio, {Fernando J.}",

note = "Funding Information: This work is supported by the National Science Foundation Engineering Research Center on Structured Organic Particulate Systems , through grant NSF-ECC 0540855 , and by grant NSF-0504497 .",

year = "2013",

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language = "English (US)",

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journal = "Powder Technology",

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TY - JOUR

T1 - Scale-up strategy for continuous powder blending process

AU - Gao, Yijie

AU - Muzzio, Fernando J.

N1 - Funding Information: This work is supported by the National Science Foundation Engineering Research Center on Structured Organic Particulate Systems , through grant NSF-ECC 0540855 , and by grant NSF-0504497 .

PY - 2013/2

Y1 - 2013/2

N2 - Continuous powder mixing has attracted a lot of interest within the pharmaceutical industry. Much work has been done recently that targets the characterization of continuous powder mixing. In this paper, a quantitative scaling up strategy is introduced that allows the transition from lab to industrial scale. The proposed methodology is based on the variance spectrum analysis, and the residence time distribution, which are key indexes in capturing scale-up of the batch-like mixing, and scale-up of the axial mixing and motion, respectively. Our simulation results are used as preliminary guidance for scaling up different powder mixing cases.

AB - Continuous powder mixing has attracted a lot of interest within the pharmaceutical industry. Much work has been done recently that targets the characterization of continuous powder mixing. In this paper, a quantitative scaling up strategy is introduced that allows the transition from lab to industrial scale. The proposed methodology is based on the variance spectrum analysis, and the residence time distribution, which are key indexes in capturing scale-up of the batch-like mixing, and scale-up of the axial mixing and motion, respectively. Our simulation results are used as preliminary guidance for scaling up different powder mixing cases.

KW - DEM

KW - Periodic section modeling

KW - Powder blending

KW - RTD

KW - Sample size

KW - Scale-up

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DO - https://doi.org/10.1016/j.powtec.2012.09.036

M3 - Article

VL - 235

SP - 55

EP - 69

JO - Powder Technology

JF - Powder Technology

SN - 0032-5910

ER -

Scale-up strategy for continuous powder blending process

Abstract

ASJC Scopus subject areas

Keywords

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