Seasonal cycling in the gut microbiome of the Hadza hunter-gatherers of Tanzania

Samuel A. Smits, Jeff Leach, Erica D. Sonnenburg, Carlos G. Gonzalez, Joshua S. Lichtman, Gregor Reid, Rob Knight, Alphaxard Manjurano, John Changalucha, Joshua E. Elias, Maria Gloria Dominguez-Bello, Justin L. Sonnenburg

Research output: Contribution to journalArticlepeer-review

256 Scopus citations

Abstract

Although humans have cospeciated with their gut-resident microbes, it is difficult to infer features of our ancestral microbiome. Here, we examine the microbiome profile of 350 stool samples collected longitudinally for more than a year from the Hadza hunter-gatherers of Tanzania. The data reveal annual cyclic reconfiguration of the microbiome, in which some taxa become undetectable only to reappear in a subsequent season. Comparison of the Hadza data set with data collected from 18 populations in 16 countries with varying lifestyles reveals that gut community membership corresponds to modernization: Notably, the taxa within the Hadza that are the most seasonally volatile similarly differentiate industrialized and traditional populations. These data indicate that some dynamic lineages of microbes have decreased in prevalence and abundance in modernized populations.

Original languageEnglish (US)
Pages (from-to)802-805
Number of pages4
JournalScience
Volume357
Issue number6353
DOIs
StatePublished - Aug 25 2017
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General

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