Abstract
This work describes the selective targeting of pigmented retinal pigment epithelial (RPE) cells by a single pulsed laser irradiation. We observed: (1) single pulsed laser irradiation caused cellular damages on pigmented, and not on non-pigmented RPE cells at laser radiant exposure up to 2550 mJ/cm2; (2) in the mixture of pigmented and non-pigmented RPE cells, single pulsed laser-induced damage was confined to pigmented RPE cells. This study demonstrates that the pigmented RPE cells can be selectively damaged, using a single pulsed laser irradiation, without thermal coagulation to adjacent non-pigmented RPE cells.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 10518-10528 |
| Number of pages | 11 |
| Journal | Optics Express |
| Volume | 16 |
| Issue number | 14 |
| DOIs | |
| State | Published - Jul 7 2008 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Atomic and Molecular Physics, and Optics
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Selective targeting of pigmented retinal pigment epithelial (RPE) cells by a single pulsed laser irradiation : An in vitro study. / Song, Q.; Risco, R.; Latina, M.; Berthiaume, Francois; Nahmias, Y.; Yarmush, Martin.
In: Optics Express, Vol. 16, No. 14, 07.07.2008, p. 10518-10528.Research output: Contribution to journal › Article
TY - JOUR
T1 - Selective targeting of pigmented retinal pigment epithelial (RPE) cells by a single pulsed laser irradiation
T2 - An in vitro study
AU - Song, Q.
AU - Risco, R.
AU - Latina, M.
AU - Berthiaume, Francois
AU - Nahmias, Y.
AU - Yarmush, Martin
PY - 2008/7/7
Y1 - 2008/7/7
N2 - This work describes the selective targeting of pigmented retinal pigment epithelial (RPE) cells by a single pulsed laser irradiation. We observed: (1) single pulsed laser irradiation caused cellular damages on pigmented, and not on non-pigmented RPE cells at laser radiant exposure up to 2550 mJ/cm2; (2) in the mixture of pigmented and non-pigmented RPE cells, single pulsed laser-induced damage was confined to pigmented RPE cells. This study demonstrates that the pigmented RPE cells can be selectively damaged, using a single pulsed laser irradiation, without thermal coagulation to adjacent non-pigmented RPE cells.
AB - This work describes the selective targeting of pigmented retinal pigment epithelial (RPE) cells by a single pulsed laser irradiation. We observed: (1) single pulsed laser irradiation caused cellular damages on pigmented, and not on non-pigmented RPE cells at laser radiant exposure up to 2550 mJ/cm2; (2) in the mixture of pigmented and non-pigmented RPE cells, single pulsed laser-induced damage was confined to pigmented RPE cells. This study demonstrates that the pigmented RPE cells can be selectively damaged, using a single pulsed laser irradiation, without thermal coagulation to adjacent non-pigmented RPE cells.
UR - http://www.scopus.com/inward/record.url?scp=47249097946&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=47249097946&partnerID=8YFLogxK
U2 - https://doi.org/10.1364/OE.16.010518
DO - https://doi.org/10.1364/OE.16.010518
M3 - Article
C2 - 18607465
VL - 16
SP - 10518
EP - 10528
JO - Optics Express
JF - Optics Express
SN - 1094-4087
IS - 14
ER -