Selective targeting of pigmented retinal pigment epithelial (RPE) cells by a single pulsed laser irradiation: An in vitro study

Q. Song, R. Risco, M. Latina, Francois Berthiaume, Y. Nahmias, Martin Yarmush

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

This work describes the selective targeting of pigmented retinal pigment epithelial (RPE) cells by a single pulsed laser irradiation. We observed: (1) single pulsed laser irradiation caused cellular damages on pigmented, and not on non-pigmented RPE cells at laser radiant exposure up to 2550 mJ/cm2; (2) in the mixture of pigmented and non-pigmented RPE cells, single pulsed laser-induced damage was confined to pigmented RPE cells. This study demonstrates that the pigmented RPE cells can be selectively damaged, using a single pulsed laser irradiation, without thermal coagulation to adjacent non-pigmented RPE cells.

Original languageEnglish (US)
Pages (from-to)10518-10528
Number of pages11
JournalOptics Express
Volume16
Issue number14
DOIs
StatePublished - Jul 7 2008
Externally publishedYes

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pigments
pulsed lasers
irradiation
cells
damage
coagulation
lasers

All Science Journal Classification (ASJC) codes

  • Atomic and Molecular Physics, and Optics

Cite this

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abstract = "This work describes the selective targeting of pigmented retinal pigment epithelial (RPE) cells by a single pulsed laser irradiation. We observed: (1) single pulsed laser irradiation caused cellular damages on pigmented, and not on non-pigmented RPE cells at laser radiant exposure up to 2550 mJ/cm2; (2) in the mixture of pigmented and non-pigmented RPE cells, single pulsed laser-induced damage was confined to pigmented RPE cells. This study demonstrates that the pigmented RPE cells can be selectively damaged, using a single pulsed laser irradiation, without thermal coagulation to adjacent non-pigmented RPE cells.",
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Selective targeting of pigmented retinal pigment epithelial (RPE) cells by a single pulsed laser irradiation : An in vitro study. / Song, Q.; Risco, R.; Latina, M.; Berthiaume, Francois; Nahmias, Y.; Yarmush, Martin.

In: Optics Express, Vol. 16, No. 14, 07.07.2008, p. 10518-10528.

Research output: Contribution to journalArticle

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