Sensitivityof 3-Dimensional sonography in preoperativeevaluationofparathyroid glands inpatients with primary hyperparathyroidism

Research output: Contribution to journalArticle

Abstract

Objectives—Preoperative localization of parathyroid adenomas in patients with primary hyperparathyroidism facilitates targeted surgery. We assessed the sensitivity of 3-dimensional (3D) sonography for preoperative localization of abnormal parathyroid glands. Methods—We conducted a retrospective review of patients who underwent parathyroidectomy for primary hyperparathyroidism at a single site at our institution. We compared preoperative 2-dimensional (2D) sonography, 3D sonography, and sestamibi scans with final gland localization at surgery. Two readers reviewed the sonograms to assess inter-reader variability. Results—From January 2010 through April 2015, 52 patients underwent parathyroidectomy after preoperative 2D sonography, 3D sonography, and sestamibi scans. Three-dimensional sonography had sensitivity of 88–92% compared with 69–71% for 2D sonography for gland localization. In patients in whom sonography and sestamibi scans localized abnormalities to the same side, the sensitivities were 100% (43 of 43) for 3D sonography and 96% (48 of 50) for 2D sonography. Threedimensional sonography had significantly higher sensitivity for localization of glands smaller than 500 mg compared with 2D sonography (88% versus 58%; P5.012). There was better inter-reader agreement between the radiologists when using 3D sonography (j50.65) compared with 2D sonography (j50.41). Conclusions—We found a significantly higher sensitivity and better inter-reader agreement for 3D sonography compared with 2D sonography for preoperative identification of abnormal parathyroid glands, especially among smaller glands.

Original languageEnglish (US)
Pages (from-to)1897-1904
Number of pages8
JournalJournal of Ultrasound in Medicine
Volume36
Issue number9
DOIs
StatePublished - Jan 1 2017

Fingerprint

Primary Hyperparathyroidism
Inpatients
Ultrasonography
Parathyroidectomy
Parathyroid Glands
Parathyroid Neoplasms

All Science Journal Classification (ASJC) codes

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging

Keywords

  • 3-Dimensional sonography
  • Head and neck ultrasound
  • Hyperparathyroidism
  • Parathyroid adenoma

Cite this

@article{05a8ee40fdc54853b4847d27b17f6dc8,
title = "Sensitivityof 3-Dimensional sonography in preoperativeevaluationofparathyroid glands inpatients with primary hyperparathyroidism",
abstract = "Objectives—Preoperative localization of parathyroid adenomas in patients with primary hyperparathyroidism facilitates targeted surgery. We assessed the sensitivity of 3-dimensional (3D) sonography for preoperative localization of abnormal parathyroid glands. Methods—We conducted a retrospective review of patients who underwent parathyroidectomy for primary hyperparathyroidism at a single site at our institution. We compared preoperative 2-dimensional (2D) sonography, 3D sonography, and sestamibi scans with final gland localization at surgery. Two readers reviewed the sonograms to assess inter-reader variability. Results—From January 2010 through April 2015, 52 patients underwent parathyroidectomy after preoperative 2D sonography, 3D sonography, and sestamibi scans. Three-dimensional sonography had sensitivity of 88–92{\%} compared with 69–71{\%} for 2D sonography for gland localization. In patients in whom sonography and sestamibi scans localized abnormalities to the same side, the sensitivities were 100{\%} (43 of 43) for 3D sonography and 96{\%} (48 of 50) for 2D sonography. Threedimensional sonography had significantly higher sensitivity for localization of glands smaller than 500 mg compared with 2D sonography (88{\%} versus 58{\%}; P5.012). There was better inter-reader agreement between the radiologists when using 3D sonography (j50.65) compared with 2D sonography (j50.41). Conclusions—We found a significantly higher sensitivity and better inter-reader agreement for 3D sonography compared with 2D sonography for preoperative identification of abnormal parathyroid glands, especially among smaller glands.",
keywords = "3-Dimensional sonography, Head and neck ultrasound, Hyperparathyroidism, Parathyroid adenoma",
author = "Libutti, {Steven K.}",
year = "2017",
month = "1",
day = "1",
doi = "https://doi.org/10.1002/jum.14245",
language = "English (US)",
volume = "36",
pages = "1897--1904",
journal = "Journal of Ultrasound in Medicine",
issn = "0278-4297",
publisher = "American Institute of Ultrasound in Medicine",
number = "9",

}

TY - JOUR

T1 - Sensitivityof 3-Dimensional sonography in preoperativeevaluationofparathyroid glands inpatients with primary hyperparathyroidism

AU - Libutti, Steven K.

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Objectives—Preoperative localization of parathyroid adenomas in patients with primary hyperparathyroidism facilitates targeted surgery. We assessed the sensitivity of 3-dimensional (3D) sonography for preoperative localization of abnormal parathyroid glands. Methods—We conducted a retrospective review of patients who underwent parathyroidectomy for primary hyperparathyroidism at a single site at our institution. We compared preoperative 2-dimensional (2D) sonography, 3D sonography, and sestamibi scans with final gland localization at surgery. Two readers reviewed the sonograms to assess inter-reader variability. Results—From January 2010 through April 2015, 52 patients underwent parathyroidectomy after preoperative 2D sonography, 3D sonography, and sestamibi scans. Three-dimensional sonography had sensitivity of 88–92% compared with 69–71% for 2D sonography for gland localization. In patients in whom sonography and sestamibi scans localized abnormalities to the same side, the sensitivities were 100% (43 of 43) for 3D sonography and 96% (48 of 50) for 2D sonography. Threedimensional sonography had significantly higher sensitivity for localization of glands smaller than 500 mg compared with 2D sonography (88% versus 58%; P5.012). There was better inter-reader agreement between the radiologists when using 3D sonography (j50.65) compared with 2D sonography (j50.41). Conclusions—We found a significantly higher sensitivity and better inter-reader agreement for 3D sonography compared with 2D sonography for preoperative identification of abnormal parathyroid glands, especially among smaller glands.

AB - Objectives—Preoperative localization of parathyroid adenomas in patients with primary hyperparathyroidism facilitates targeted surgery. We assessed the sensitivity of 3-dimensional (3D) sonography for preoperative localization of abnormal parathyroid glands. Methods—We conducted a retrospective review of patients who underwent parathyroidectomy for primary hyperparathyroidism at a single site at our institution. We compared preoperative 2-dimensional (2D) sonography, 3D sonography, and sestamibi scans with final gland localization at surgery. Two readers reviewed the sonograms to assess inter-reader variability. Results—From January 2010 through April 2015, 52 patients underwent parathyroidectomy after preoperative 2D sonography, 3D sonography, and sestamibi scans. Three-dimensional sonography had sensitivity of 88–92% compared with 69–71% for 2D sonography for gland localization. In patients in whom sonography and sestamibi scans localized abnormalities to the same side, the sensitivities were 100% (43 of 43) for 3D sonography and 96% (48 of 50) for 2D sonography. Threedimensional sonography had significantly higher sensitivity for localization of glands smaller than 500 mg compared with 2D sonography (88% versus 58%; P5.012). There was better inter-reader agreement between the radiologists when using 3D sonography (j50.65) compared with 2D sonography (j50.41). Conclusions—We found a significantly higher sensitivity and better inter-reader agreement for 3D sonography compared with 2D sonography for preoperative identification of abnormal parathyroid glands, especially among smaller glands.

KW - 3-Dimensional sonography

KW - Head and neck ultrasound

KW - Hyperparathyroidism

KW - Parathyroid adenoma

UR - http://www.scopus.com/inward/record.url?scp=85046029530&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85046029530&partnerID=8YFLogxK

U2 - https://doi.org/10.1002/jum.14245

DO - https://doi.org/10.1002/jum.14245

M3 - Article

C2 - 28543268

VL - 36

SP - 1897

EP - 1904

JO - Journal of Ultrasound in Medicine

JF - Journal of Ultrasound in Medicine

SN - 0278-4297

IS - 9

ER -